Clinical Observation And Experimental Study Of Bone Marrow Inhibition Of Chemotherapy In Patients With Lung Cancer

The research purpose and significance of this topic:this subject of "Yin and Yang mutual root" based on the theory of Zhang Jingyue, using Fu Yang Yisui Decoction prevention of dry treatment after chemotherapy of lung cancer of the bone marrow inhibit adverse reactions, through clinical observation and experimental study to explore TCM "Yang for Yin" theory in lung cancer adjuvant chemotherapy treatment in the treatment of scientific connotation, so as to enrich the tumour of doctor of traditional Chinese medicine Fu Yang treatment and improve the efficacy.Methods:the clinical observation and experimental study of two kinds of methods1, clinical observationCollect 50 cases of disease belongs to deficiency of lung and Spleen Yang (QI), Qi and yin deficiency type of chemotherapy in advanced lung cancer patients, according to the principle of random, patients were divided into treatment group and control group, the chemotherapy were according to the standard of chemotherapy. In the treatment group before chemotherapyfor 3 days to start taking Fuyang Yisui Decoction in patients with lung cancer, taking a total of 7 days. The control group did not take lung cancer chemotherapy patients with traditional Chinese medicine preparation. Chemotherapy for 3 days before the blood tests and chemotherapy after the 1,3,5 day review of blood, in the taking of Fu Yang Yisui Decoction first day and taking over the next day check immune index, tumor associated antigen, KPS score and clinical symptoms, control group and treatment group on the same day inspection were observed in bone marrow inhibition rate and extent.2, experimental study72 male black rat were randomly divided into 6 groups, help Yang Yi Sui group, Yiqi group, nourishing Yin group, chemotherapy group, denominated alcohol group and blank group,12 rats in each group. The 1-3 day Fu Yang Yi Sui group (concentration:0.504g crude drug/ml dose:15mg/kg), Yiqi group (concentration:0.390g crude drug/ml dose:15mg/kg), nourishing Yin group (concentration:0.360g crude drug/ml dose:15mg/kg), batyl alcohol group 0.14g/kg mice were given drugs by gavage, chemotherapy group and the control group given normal saline 0.2ml/20g gavage. On the fourth day began to help Yang Yi Sui group, Yiqi group, nourishing Yin group, batyl alcohol group, chemotherapy group with intraperitoneal injection of cisplatin.9mg/kg, injection, the 5-8 days continue to according to the former drug and saline by gavage. Ninth days all the mice blood, broken marrow is put to death, andcollection of peripheral blood cells, spleen and thymus.Results:1, clinical observationChanges of hemogram index:treatment group white cells compared with the control group compared with statistical significance (P< 0.05), and neutrophil cell, hemoglobin, red blood cell, platelet and the control group compared had no statistical significance (P> 0.05).Treatment group after treatment in patients with God fatigue, less words lazy language, pale white Huang, appetite loss and before treatment and after treatment in the control group were statistically significant (P<0.05). After treatment with chemotherapy group and chemotherapy before comparing changes in KPS has significant difference (P<0.01), the treatment group and the control group chemotherapy after compared KPS has differences (P< 0.05). The treatment group of T lymphocyte subsets CD3+, CD4+, CD8+and CD4+/CD8+ had nostatistical significance (P>0.05). Comparison of tumor associated antigen:two between treatment groups showed no significant difference (P>0.05). There is no significant difference between the treatment group and the control group (P>0.05). Although there is no statistical significance, but chemotherapy group before and after treatment, tumor associated antigen was decreased; in the treatment group decreased compared with the control group.2, experimental study White blood cells:blank group and the chemotherapy group have significant difference (P< 0.01); Fu Yang and tonifying marrow group and chemotherapy group have significant difference (P< 0.01); shark liver alcohol group and the chemotherapy group with difference (P < 0.05). Red blood cell:Yin group and chemotherapy group, chemotherapy group and control group there was significant difference (P<0.01). Hemoglobin:chemotherapy group and blank group, Yiqi Decoction "and chemotherapy group, nourishing yin and the chemotherapy group have significant difference ((P<0.02). Spleen index:Fuyang Yisui group, batyl alcohol group,control group and cisplatin group had significant difference (P<0.05). Thymus index:there were significant differences in the chemotherapy group and the control group (P<0.01);Fuyang Yisui group and chemotherapy group differences (P<0.05).Conclusion:1, clinical observationFu Yang Yisui Decoction in clinical practice can improve disease belongs to deficiency of lung and Spleen Yang (QI), bone marrow suppression after chemotherapy of advanced lung cancer patients in the type of deficiency of both qi and Yin of clinical symptoms. Taking a set of Fu Yang Yisui decoction is not taking a group KPS has statistical significance that Fu Yang Yisui decoction can improve the disease belongs to the type of deficiency of lung and Spleen Yang (QI), Qi and yin deficiency type of advanced lung cancer patients with lung cancer chemotherapy patients quality of life. Fuyang Yisui decoction can increase the peripheralblood, especially for white blood cells increased, bone marrow suppression rate decreased.No statistical difference in clinic to improve the immune function of the organism may be related to the observation time is short, but further research. In the inhibition of tumor, although there was no statistically significant, but chemotherapy group before and after treatment, tumor associated antigen was decreased; the treatment group decreased trend and control group were compared.2, experimental studyThe Fuyang Yisui decoction can improve the mice after chemotherapy and peripheral blood,has certain protective effect of bone marrow. Ⅱ Fu Yang Yisui decoction can improved after chemotherapy in mice spleen index and thymus index, the role of certain improve the body’s immune system, with reduce chemotherapy side effects.Research results suggest that:Traditional Chinese medicine Fuzheng treatment are to chemotherapy has certain protection to bone marrow and increase of peripheral blood cells and the clinical use of more is the prescription for supplementing qi, nourishing yin and enriching the blood, etc., this study showed that:Fu Yang treatment also has a good protective effect on the bone marrow, results from a confirmed the TCM "Yang for Yin" theory scientific connotation.