Epidemiological Profile And Clinical Characteristics Analysis Of Liver Fluke Disease In Fuyu Country,jilin

Objective:To explore the epidemiological profile and clinical characteristics of liver flukedisease in Fuyu county,Jilin,so as to improve the understanding of liver fluke disesaand achieve early detection、early diagnosis、early treatment,and ultimately reduce theincidence of liver fluke disease occurrence,recurrence and its coplications.Methods:A total of443local residents(excluding hepatitis B,hepatitis C-infectedpatients),including344had liver fluke infection(they smear found liver fluke eggs),99without liver fluke infection.All respondents were fill out the epidemiologicalsurvey,and check liver function,blood lipids,abdominal ultrasound.Results:1.In344patients with liver fluke infection,the proportion of men and women were64.8%(223/344),35.2%(121/344) respectively(P=0.001).The prevalence in the malewas generally higher than that in the female.Age distribution from8-82, mean agewas50.Among344patients with liver fluke infection,98.8%were adutle.As thegrowth of the age,the increase of liver fluke infection,and reaches the highest in theage group of41-50and51-60,32.3%,31.4%respectively.Liver fluke infection haddeclined after60years.2.In344patients with liver fluke infection,the percentage of individuals who hadheard of liver fluke disease,knowing the the harm was65.1%and25.3%,respectively.The percentage of eating raw fish was87.9%.The behavior of eating rawfish was differential among females and males,65.3%and87.9%, respectively（p＜0.001）.3.In this study,344patients with liver fluke infection,with fatigue12patients(3.5%),abdominal distention7cases(2.0%),liver pain9cases (0.6%),loss ofappetite3cases (0.9%),weight loss2case (0.6%),nausea4cases(1.2%),frequent diarrhea10patients(2.9%),upper abdominal discomfort10cases(2.9%),AST increased32cases(7.3%),ALT increased8cases(2.3%),ALP increased25cases (7.3%),γ-GTincreased26cases (7.6%),TBIL increased6cases (1.7%),blood lipids increased109cases(31.7%).4.The percentage of liver fluke disease patients combine with fatty liver、gallbladder stones and the change of bile were64.8%,12.5%,71.5%,respectively.Liver fluke disease patients’ γ-GT was30（18-57）,blood lipid wasCHOL4.4（3.8-4.9）、TRIG1.62（1.03-2.43）. The percentage of without liver flukedisease patients combine with fatty liver、gallbladder stones and the change of bilewere9.1%、5.1%、15.2%.Without liver fluke disease patients’ γ-GT was19（14-36）,blood lipid was CHOL3.9（3.6-4.7）、TRIG1.21（0.89-2.03）.(P＜0.05)Conclusinon：1.As the growth of the age,the increase of liver fluke infection,and reaches thehighest in the age group of41-60.It was found that the prevalence in the male wasalmost2times in the female,the distribution characteristics was relate to human rawfish-eating behavior.2.The percentage of individuals who had heard of liver fluke disease was65.1%,while the individuals being aware of the harm of liver fluke disease was only25.3%.This reminded clinicians to strengthen the liver fluke disease hazards andpublic education, and to reduce the incidence of liver fluke disease and recurrence.3.Liver fluke infection was relation to fatty liver,gallbladder stones,hyperlipidemia and bile duct wall thickening, echogenicity.4.γ-GT lifts was relation to liver fluke infection in liver function test,this alterclinicians were aware of the liver fluke disease examination.