Clinical Significance Of Tumor Marker In The Diagnosis Of Lung Cancer

Background:Lung cancer patients often do not exhibitspecific symptoms, particularly in early stages. Therefore,the majority of lung cancer patients are diagnosed at anadvanced stage,which undermines their effective treatment.Currently, conventional diagnostic tests such as chestradiographs, computed tomography scans, and fiber opticbronchoscopy are not sensitive enough for effective earlydetection.Meanwhile, the benign pulmonary nodules andmalignanttumors cannot be distinguished by imaging methodscurrently.Tumor markers are molecules occurring in blood ortissue that are produced by a tumour associated with a canceror by the host in response to the cancer. Tumor markers can beused for screening a high risk population for cancer, makinga diagnosis and prognosis in a specific cancer and monitoringthe course in a patient in remission or while receiving surgery,radiation, or chemotherapy.Objective： To investigate the value of serum tumormarkers,such as carcinoembryonic antigen (CEA), tumorassociated antigen199(CA199), tumor associated antigen125 (CA125), neuron specific enolase (NSE),and combined detectionin the diagnosis of lung cancer.Methods：CEA, CA199, CA125and NSE of174patients with lungcancer, detected by electrochemical luminescence method, werecompared with99patients with Lung benign disease and42peoplefrom health checkup to analyse of serum tumor markers CEA, CA199,CA125and NSE in the diagnosis of lung cancer.Results：(1)In lung cancer group, levels of CEA, CA199,CA125and NSE were significantly higher than those of benignlung disease group and the healthy group (P＜0.05).Nosignificant difference was found between the lung benigndisease group and healthy group (P＞0.05).(2)Thesensitivities of CEA, CA199, CA125and NSE in the diagnosis oflung cancer are49.13%,17.92%,31.79%,40.46%respectively.The sensitivity of combined detection in diagnosis of lungcancer, as high as60.69%, has a significant difference witheach individual detection in diagnosis of lung cancer (P＜0.05).(3) The level of serum CEA of lung adenocarcinoma has asignificant difference with the other two pathology type (P＜0.05). The level of serum NSE of small cell lung carcinomahas a significant difference with the other two pathology type(P＜0.05), no significant difference of serum CA199, CA125 levels in three different pathologic types of difference (P＜0.05).Conclusion：The levels of serum tumor markers CEA, NSE arerelated to pathological types of lung cancer, and he levels ofserum tumor markers CA199CA125are unrelated to pathologicaltypes of lung cancer, The combined detection can be used as anauxiliary means for early diagnosis of lung cancer, and isbeneficial for early detection, early treatment.