Analysis Of Related Risk Factors Of Cranial Artery Atherosclerosis In Elderly Males

Aims:The aim of this study is to determine the extent of carotid atherosclerosisin elderly Chinese males in relation to the cumulative atherosclerosis risk factors,such as hypertension, diabetes, smoke and so on, using ultrasonography.Methods: Males who took examination and reviewed in the next year in theBethune First Hospital of Jilin University, aged75and over, were included in thestudy. Their test results of artery ultrasound, physical examination, medical history,laboratory tests were carried out a systematic review and comprehensive analysis.Results:①Overall distribution: The study included elderly Chinese males inJilin province, who were83(8) years old. The prevalence of hypertension,dyslipidemia, diabetes, kidney dysfunction were60.6%,53.7%,23.42%,3.9%respectively; rate of baseline plaque detection was91.1%, the annual incidence ofstroke was3.45%.②Age differences: The rate of plaque detection increased as age(88.0%,90.1%,93.5%,100%), for subjects aged≥80years, rate of plaque progressionincreased as age (26.0%,31.9%,55.6%)(P=0.055), the annual incidence of strokeincreases as age (1.80%,2.45%,5.85%,5.55%)(P=0.165).③Risk factors: Age is theindependent risk factor for progression atherosclerosis(P=0.023，OR=1.066) andstroke(P=0.044,OR=1.696); age(P=0.035), hypertension(P=0.002) anddiabetes(P=0.014) are the risk factors for atherosclerosis, hypertension(P=0.003，OR=2.275) and age(P=0.025， OR=1.063) are the independent risk factors foratherosclerosis; taking Asprin (P=0.043，OR=0.275） is the protective factor foratherosclerotic progression; high-CHOL (P=0.029, OR=2.55), high-TG (P=0.032)and low-HDL-C (（P=0.026, OR=8.267) are the risk factors for progression of plaque,high-HDL-C (P=0.078，OR=0.453) is the protective factor for progression of plaque,high-TG (P=0.006，OR=1.583) is the independent risk factor for progression ofplaque; low-URIC (P=0.039) in the normal limits is the risk factor for progression ofplaque.④Cumulative effects: The rate of plaque detection was increasing as thenumber of the cumulative risk factors(88.9%,88.9%,100%); the rate of plaque progression increased as the number of the cumulative risk factors(28.6%,34.7%,42.3%);Conclusion:1. In the study, the rate of carotid artery atherosclerotic plaquedetection of elderly males aged75+is91.1%, the annual incidence of stroke is3.45%,rate of plaque detection, abnormal IMT rate, progression of IMT are increasing withage, the incidence of stroke of males aged75to89is increasing with age.2. For≥75years old males, age, hypertension, diabetes is the risk factors for atherosclerosis, ageand hypertension are independent risk factors for atherosclerosis. Taking Asprin is theprotective factor for progression of atherosclerosis. Age is an independent risk factorfor progression of atherosclerosis.3. For≥75years old males, high-CHOL levels,high-TG levels, low-HDL-C, high-CHOL hyperlipidemia are risk factors forprogression of plaque, high-HDL levels are protective factors of progression of plaque,high-TG levels is the independent risk factor for progression of plaque. Lower levelsof uric acid is a risk factor for detection of plaque.4. For≥75year old males, age is anindependent risk factor for stroke, the incidence of stroke has no significantcorrelation with carotid atherosclerosis and progression of carotid stenosis.5.Hypertension, diabetes, dyslipidemia, smoke and other risk factors have cumulativeeffects on carotid atherosclerosis of the elderly males aged75and over.