Relevant Factor Analysis Of Kindey Damage Patients With Henoch-schonlein Purpura

Objective:To summarize the general rules of the patients with HSP，investigate the riskfactors of kidney damage and sensitive indexes for early diagnosis of kidney damagethough retrospectively analysing the data of the128patients with HSP.Methods： One hundred and twenty-eight patients with HSP of dermatologicaldepartment were collected (from January2011to December2013）.By analyzing theclinical classifications, initial symptoms and causes, summarize the general rules ofHSP.According to the clinical manifestations of kidney damage,we divide the patientsinto two groups，kidney damage group with71cases and no kidney damage group with57cases.Through comparing the differences between the two groups of patients’ age、sex、clinical symptoms and laboratory examinations, analyze the risk factors of renaldamage and sensitive indexes for early diagnosis of kidney damage in patients withHSP.Analyze the data using SPSS10.0software and compare the difference of the databetween the two groups using χ2-test or t-test.It has statistical difference whenP<0.05.Results:1、The clinical data： Age：the average age of kidney damage group is(37.73±18.21),the group is older than the other（t=2.112，P<0.05）. Sex： the ratioof male to female between the two group has no statistical difference (χ2=0.335，P>0.05). Presence of gastrointestinal symptoms： the proportion of patients withgastrointestinal symptoms in the kidney damage group is greater than in the no kidneydamage group.The differene is statistically significan（tχ2=8.397，P<0.01）.④Presence of joint symptoms：the proportion of patients with joint symptoms between the twogroup has no statistical difference（χ2=0.032，P>0.05）.2、The laboratory data：31patients’ ASO inereased,including23cases in the kidney damage group and8cases inthe no kidney damage group. The proportion of patients with elevated ASO in thekidney damage group is higher than in the no kidney damage group.The differene isstatistically significant（χ2=5.807，P<0.05）.31patients’ ESR inereased,including30in the kidney damage group and22in the no kidney damage group, without statisticaldifference（χ2=0.175，P>0.05）.42patients’ CRP inereased,including24in the kidneydamage group and18in the no kidney damage group,without statistical difference（χ2=0.071，P>0.05）.38patients’ IgA inereased,including28in the kidney damage groupand10in the no kidney damage group.The proportion of patients with elevated IgA inthe kidney damage group is higher than in the no kidney damage group.The differene isstatistically significant（χ2=7.259，P<0.01）.70patients’ IgE inereased,including42inthe kidney damage group and28in the no kidney damage group,without statisticaldifference（χ2=1.284，P>0.05）.31patients’ C3inereased,including19in the kidneydamage group and12in the no kidney damage group,without statistical difference（χ2=0.561,P>0.05）.34patients’ PLT increased,including34in the kidney damage groupand15in the no kidney damage group.The proportion of patients with high plateletcount in the kidney damage group is higher than in the no kidney damage group,withstatistical difference（χ2=6.227，P<0.05).62patients’ WBC inereased,including42inthe kidney damage group and20in the no kidney damage.The proportion of patientswith high white blood cell in the kidney damage group is higher than in the no kidneydamage group. the differene is statistically significant（χ2=7.332，P<0.01).3、Indexesfor diagnosis of kidney damage：the average U-Alb content in the kidney damagegroup is（39.34±13.59）mg/24h,the average U-Alb content in the no kidney damagegroup i（s20.76±17.98）mg/24h.The average U-Alb content in the kidney damage groupis higher than in the no kidney damage group.The U-Alb content between the two groups has statistically significant difference（t=6.657，P<0.01）.The average Cr contentand BUN content in the two groups have no statistical significance.Conclusion:1、Age、gastrointestinal symptoms、elevated ASO、elevated IgA、high PLT count and high WBC count are related to kidney damage.2、Sex、jointsymptoms、elevated ESR、elevated CRP、elevated IgE and elevated C3are not obviouslyrelated to kidney damage.3、U-Alb is a sensitive index for early diagnosis of kidneydamage.