Studys On The Inter-relationship Between The IL-6,TNF-α And Phospholipid Fatty Acids Spectrum In Metabolic Syndrome

Background:The metabolic syndrome (MS) is a variety of metabolic abnormalities occur simultaneously in the same individual clinical phenomenon, insulin resistance is a central part of the metabolic syndrome. Insulin resistance is largely related to genetic factors.But environment and way of life can lead to insulin resistance, and especially the intake of dietary fat and total species play a very important role in it. Essential polyunsaturated fatty acids and closely related to chronic noncommunicable diseases, can affect blood pressure blood fat and thrombosis, prevention cardiovascular ischemic lesions of patients with type2diabetes mellitus and reducing visceral fat area of serum phospholipid fatty acids relative to free fatty acids that can better reflect the habits of dietary fatty acids composition in recent years.Studies have found that low-grade systemic chronic inflammation is the emphasis of the metabolic syndrome (MS) and a number of abnormal composition of join points.The metabolic syndrome (MS) in patients with partial inflammation factors, such as Interleukin6(Interleukin-6, IL-6), Tumor necrosis factor alpha (Tumor necrosis factor alpha, TNF alpha) levels but at the moment about dietary fatty acids and inflammatory factor in the research report.Objectives:By measuring the metabolic syndrome (MS) group and healthy control group of serum phospholipid fatty acid composition and Interleukin6(Interleukin-6, IL-6), Tumor necrosis factor alpha (Tumor necrosis factor alpha, TNF alpha), the data comparative analysis, discuss with MS patients serum inflammatory markers PUFA and the relationship between the various metabolic abnormalities.Methods:(1) By ELIS A method of determination of serum Interleukin6(Interleukin-6, IL-6) and Tumor necrosis factor alpha (Tumor necrosis factor alpha, TNF alpha) horizontal.(2) Gas chromatography determination of phospholipid fatty acids with SPSS16.0statistical treatment, P<0.05as there are significant differences.Results:IL-6and SFA into positive correlation, and the C16:0, C18:0C20:0C23:0C24:0into positive correlation; Negative correlation with PUFA with n-6PUFA C18:3n-3C22:2n-6C22:5n-3negative correlation, negative correlation with PUFA/SFA; With the C16MUFA:1C20:1negative correlation.TNF-a with SFA in C24:0into positive correlation; Of MUFA C16:1C20:1; With the C22PUFA:2n-6C22:5n-3negative correlation.Conclusion:Serum IL-6,TNF-a level associated with different kinds of dietary fatty acids, increased intake of PUFA will help decrease the IL-6,TNF-a level, reduce the inflammatory response in patients with MS, has a protective effect in patients with MS.While SFA content increase the concentration of IL-6,TNF-a, aggravating the inflammatory response, promote the development of MS.