The Correlation Between Lipoprotein Associated Phospholipase A2and Acute Coronary Syndrome

Objective:Testing the levels of plasma Lp-PLA2and hs-CRP to discuss the relationship between the levels of plasma Lp-PLA2and hs-CRP and the scope of coronary artery lesions and the atheromatous plaque stability in patients with acute coronary syndrome(ACS) and the people with normal coronary angiography.Methods:Retrospective analysis the patients with the coronary heart disease and the people with normal coronary angiography from June2012to June2012in the first hospital of Lanzhou University. Divided into acute coronary syndrome group, stable angina group and the control group.Used ELISA to detect the levels of plasma Lp-PLA2and hs-CRP.Analysis the relationship between the levels of plasma Lp-PLA2and hs-CRP and the scope of coronary artery lesions in patients with acute coronary syndrome and the atheromatous plaque stability.Results:The levels of Lp-PLA2in acute coronary syndrome was115.01±80.74ng/ml, in stable angina group was90.82±61.58ng/ml and in control group was82.53±30.89ng/ml, the levels of Lp-PLA2was significantly higher than stable angina group and control group(P<0.05). The levels of hs-CRP was significantly higher than control group(P<0.05). Lp-PLA2and hs-CRP have no obvious correlation between the three groups. There were Correlation between Lipoprotein associated phospholipase A2and coronary artery lesion range in acute coronary syndrome. The levels of Lp-PLA2in multivessel lesions group was significantly higher than single coronary lesion group(P<0.01) and in double branch lesions was significantly higher than single coronary lesion(P<0.05). The levels of Lp-PLA2had no obvious correlation between double coronary lesion group and multivessel lesions group.Conclusions:The levels of Lp-PLA2could be used to assess the stability of atheromatous plaque indirectly and coronary artery lesions range.