The Analysis On Type2Diabetes Of810Cases Mellitus Patients

Objective: In order to explore the related factors for type II diabetes, the riskfactors for early-onset type II diabetes and type II diabetes with cardiovascular disease,a comparison was conducted between early-onset and late-onset type II diabetespatients, and the indicators included family history, age at diagnosis, anthropometricindicators, clinical and biochemical indicators and comorbidities, which mightprovide an evidence for control of cardiovascular risk factor in type II diabetespatients.Methods: A total of810type II diabetes patients (480male and330female),diagnosed from January2012to April2014, were collected from endocrinology inQiqihar Second Hospital. The cases were divided into two group according to age atdiagnosis:≤40years old for the early-onset group(350cases) and>40years old forthe late-onset group (460cases).The following indicators were compared and analyzed for all the patients: gender,age at diagnosis, smoking, positive family history of diabetes, hypertension, bodymass index (BMI), non-alcoholic fatty liver disease (NAFLD), glycated hemoglobin(HbAlc), fasting plasma glucose(FPG),2h postprandial glucose(2hPG), fastinginsulin(FINS),2h postprandial insulin (2hINS), fasting C-peptide (FC-P),2-hourpostprandial C-peptide (2hC-P), insulin resistance index (HOMA-IR), islet β cellfunction index (HOMA-β), triglyceride (TG), total cholesterol (TC), low-densitylipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), uricacid (SUA) and the concomitant diseases of type II diabetes. SPSS version21.0wasused for statistical analysis. The measurement data were compared with independentsamples t test and enumeration data were compared with Chi-square test betweengroups. The association analysis of factors used Logistic regression analysis.Results:1. The indicators in early-onset type II diabetes, including family history,smoking rates, non-alcoholic fatty liver disease detection rate and the levels of FPG,HOMA-β, TG, SUA, were higher than that in late-onset group; and the detection rateof hypertension and the levels of2hINS and HDL-C in late-onset group were higher than early-onset group.2. For male type II diabetes patients, the smoking rates, BMI and uric acid werehigher and HDL-C level lower than that in female in early-onset group, and smokingrates and SUA level were higher and HDL-C level lower than that in female inlate-onset group; for female patients in late-onset group, the proportion of type IIdiabetes family history was higher than male.3. The detection rate were36.9%and56.5%for patients combined withhypertension,26.9%and20.4%for patients combined with hyperlipidemia,12.6%and6.7%for patients combined with hyperuricemia,25.1%and15.4%for patientscombined with obesity and39.7%and28.5%for patients combined withnon-alcoholic fatty liver disease in early-onset and late-onset group respectively.In addition, the detection rate were16.9%and40.0%for patients combined withcarotid atherosclerosis,10.0%and18.0%for patients combined with angina,2.9%and7.0%for patients combined with myocardial infarction and11.1%and22.2%forpatients combined with infarction in early-onset and late-onset group respectively, andthe rate in the latter were all more than the former.4. In the early-onset type II diabetes patients combined with cardiovasculardisease, the ratio were74.7%for male and25.3%for female, and the former washigher than the latter. The patients with smoking history, hypertension and a higherlevel of HbAlc, TG, LDL-C and SUA, the detection rate combined withcardiovascular diseases was also higher.The results of multiple Logistic regression analysis showed that the increasingage, BMI, TG,2hPG, HbA1c and smoking were independent risk factors forearly-onset type2diabetes combined with cardiovascular disease.The results of univariate Logistic regression analysis showed that family historyof type2diabetes, blood pressure, smoking, BMI, triglycerides, gender and2hC-Pwere the main factors for early-onset type II diabetes; and multiple Logistic regressionanalysis showed that family history and triglyceride levels were the main risk factorsfor early-onset type II diabetes.Conclusions:1. The glucose and lipid metabolic disorders for type II diabetes patients isobviously, and the detection rates of hypertension, hyperlipidemia, hyperuricemia,obesity and non-alcoholic fatty liver disease are also higher. 2. For male with type II diabetes, the rates of history of smoking and high blooduric acid are higher and the HDL-C level is lower than female.3. Family history of type II diabetes, blood pressure, smoking, BMI, triglycerides,gender and2hC-P are the main factors for early-onset type2diabetes, and the familyhistory and triglyceride levels are the main risk factors.4. For early-onset type2diabetes combined with cardiovascular disease, theincidence in male is higher than female. Aging, smoking and the levels of2hPG, BMI,TG and HbA1c are independent risk factors for early-onset type2diabetes combinedwith cardiovascular disease.