Study On The Correlation Of Between Blood Glucose Status And Carotid Artery Plaque In Elderly Patients With Type2Diabetes Mellitu

Objective: To study on the correlation of between blood glucose status and carotid arteryplaque in elderly patients with type2diabetes mellitu.As well as the influence of fastingglucose,2h Postprandial glucose and glycosylated hemoglobin on carotid artery plaque.Methods:100cases of elderly patients with type2diabetes mellitu was selected and theirClinical characteristics were collected from Geriatrics of the First Affiliated Hospital Of TheMedical College of Shihezi University. All subjects had confirmed by diagnostic criteria. Inall patient,blood samples were collected for determination of fasting glucose,2h Postprandialglucose and glycosylated hemoglobin. Total cholesterol,triglyceride were also measured. Allthe patients of the carotid artery plaque were detected by color Doppler ultrasoundexamination to compare and to analyze the association between the blood glucose status andcarotid artery plaque.Results:1. According to the result of carotid artery color Doppler ultrasound examination, patientswere classified as four group:the none-plaque group, plaque of levelⅠgroup, plaque of levelⅡgroup,plaque of level Ⅲgroup. The results of age,TC,TG were statistically different between the groups(p<0.05). The rate of smoking and with a history of hypertension ware also statistically different in the fourgroups(p<0.05).2. All of the patients，fasting glucose、2h Postprandial glucose and glycosylated hemogl-obin were statistically significant between the none-plaque group and plaque group,the same as between differences of classification of carotid plaque (p<0.05).3.In the group of age≥75, fasting glucose、2h Postprandial glucose and glycosylated hemog-lobin were no statistically significant between the none-plaque group and plaque group (p＞0.05),there were no statistically significant in fasting glucose and2h Postprandial glucose betweendifferences of classification of carotid plaque (p＞0.05), on the contrary, glycosylated hemoglobinwere statistically significant（p<0.05）;then in the group of age<75,there were statistically signify-cant in fasting glucose、2h Postprandial glucose and glycosylated hemoglobin between thenone-plaque group and plaque group（p<0.05）, the same as between differences of classification ofcarotid plaque (p<0.05).4. Based on the glycated hemoglobin level, patients were divided into2groups:the goodblood glucose(HbA1c≤6.5%) and the poor(HbA1c>6.5%). The differences of carotid artery plaquescore and classification of carotid plaque were statistically significant between the HbA1c>6.5%group and the HbA1c≤6.5%group(p<0.05). Carotid artery plaque score and classification of carotidplaque in the HbA1c≤6.5%group was positively lower than the HbA1c>6.5%group.5. There were statistically significiant correlations between Carotid artery plaque and age, astingglucose、2h Postprandial glucose and glycosylated hemoglobin（P＜0.05）.Conclusions:1. Such as Age, smoking,a history of hypertension and hyperlipidemia were play a certain role in thedevelopment of carotid artery plaque in elderly patients with type2diabetes mellitu.2. Fasting glucose、2h Postprandial glucose and glycosylated hemoglobin were negativly correlatedwith the carotid artery plaque3. HbAlc had more significant influence on carotid artery plaque, and as the degree to carotid arteryplaque increase,HbAlc were observed in groups with more serious changes.4. there was a clear relationship between the carotid artery plaque and the glycosylatedhemoglobin.The better the level of the glycosylated hemoglobin, the lower the serious degree tocarotid artery plaque.5.Age, fasting glucose、2h Postprandial glucose and glycosylated hemoglobin were independ-ent risk factors for carotid artery plaque.