| Objective:Sanshen taste drink with righting, gas pain, temperature and other effects ofgastric stomach, gastric particles Sanshen AIDS is the use of modern technology inthe preparation of this side is made on the basis of research, while therapeuticpurposes and effects, granule formulations using more conducive to taking offerspharmacology and experimental basis for the further development of new Chinesemedicine. This study focuses on the three parameters taste particle therapypharmacodynamic studies in chronic atrophic gastritis, gastric mucosal repair,anti-inflammatory, analgesic, anti-stress and other aspects for future clinical trials forfurther preparation.Method:An analgesic effect treatment group, one hour after the last administration, allsix mice were treated by intraperitoneal injection of0.7%acetic acid at a dose of10ml/kg.5min after the start time, recording six groups writhing within10min eachmouse.anti-stress group therapy, administered1h after the first seven days, the micewere placed in six groups of all wide-mouth bottle, each bottle were installed30g limesoda, into mice after a closed bottle, tightly sealed after completion of the stopwatch,observations in mice breathing stop time, and were compared between groups.Afterthree pairs of mice affected gastrointestinal propulsive movement last administration30min, the six groups of mice were fed a10%carbon end suspension2m1/100g,20-25min later killed by cervical dislocation, laparotomy, extracted fromthe digestive tract of H. complete the end of the small intestine to the rectum,measuring a total length of carbon powder and move to the forefront of the length ofthe pylorus, calculate the percentage of carbon powder move.4anti-inflammatory effects after the last dose1hour after the rats under the fascia tothe right paw of the rats were injected1%carrageenan, each0.1ml, respectively, afterinjection1h,2h,3h,4h,5h,6h measuring the degree of swelling above7rats. pairs ofimmune function of rats after anesthesia, the rats IgG measured by agar diffusionmethod unidirectional, abdominal aortic blood RBC Cab receptor rosette test.Morphological measurements of lymphocyte transformation rate.mucosal repair weekly measurement of body weight; histological, morphological changes of gastricmucosal lesions.Results:SSZWKL large, has analgesic effects were dose and high-dose groups SSZWKLanalgesic effect is more significant.SSZWKL, the low-dose group could prolong thesurvival time of mice, there was a significant (P <0.05) difference compared with themodel group, with a significant role in hypoxia.SSZWKL small, medium-dose groupand positive control group â… difference compared with the model group weresignificantly (P <0.05), shows that particles with a certain taste Sanshen inhibition ofgastrointestinal propulsive motility effect.SSZWKL each dose group after4hoursinhibited rat paw edema occurs, and inhibition of the strongest low-dose group, therewas a significant (P <0.05) difference compared with the model group, the particleshave a distinct taste Sanshen the anti-inflammatory effects.SSZWKL after each dosegroup rat serum IgG levels, lymphocyte transformation rate, erythrocyte C3breceptor rosette rate has increased, and the obvious effect of low-dose group, therewas a significant (P difference compared with the model group <0.05), the particleshave a taste Sanshen improve immune function.SSZWKL various dose group andpositive control group compared with the model group differences were statisticallysignificant,(P <0.05).Conclusion:Sanshen AIDS stomach analgesic effect of the particles may be Corydalis, inaddition Toosendan has anti-inflammatory analgesic, Salvia also has analgesic effectblood circulation of qi and relieve pain efficacy of licorice. Sanshen AIDS stomachparticles can significantly prolong the time of death hypoxia, analysis groupconsisting of prescription medicine, which salvia, arrowroot, Yuan Hu, etc. weredecreased myocardial oxygen consumption, increases the amount of oxygen to thebody. Sanshen Zi Fang stomach particles of various drugs can promotegastrointestinal motility, for the treatment of intestinal dry constipation embolismScrophulariaceae, ebony and other traditional Chinese medicine prescription.Sanshentaste particles contained both antibacterial and anti-inflammatory effect, can suppressinflammation, reduce local tissue inflammation, so as to achieve bactericidalanti-inflammatory purposes. Sanshen taste particles prescription Scrophulariaceae,HHD, ebony and salvia can improve immune function in rats. Sanshen taste particles on gastric good repair, can be used to treat diseases of the stomach injury... |
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