Effects Of Folic Acid And Compound VitaminB Supplement On Stroke Recurrence

ObjectiveTo observe the difference of plasma homocysteine level and recurrence of stroke among primary stoke patients before and after folic acid and compound vitamin B supplementation, and analyze the the correlation between folic acid and compound vitamin B supplementation to D-dimer,fibrinoid,serum lipids level,four coagulation time and to further study the effect of folic acid and compound vitamin B on recurremce of stroke, and explore the prevention from recurrence of stroke by adding folic acid and compound vitamin B supplementation, we carried out the intervention study of supplementation of folic acid and compound vitamin B among stroke patients.MethodsIn this study,134stroke cases were selected from the department of acupuncture and moxibustion in the First Hospital Affiliated to Tianjin University of Traditional Chinese Medicine during the period of June,2009to April,2010. There are98male and36female patients. The average age is58.62±7.11year-old (from41to73year-old). All of the cases were randomly divided into folic acid and compound vitamin B intervention group and regular treatment control group and67cases in each group.8mL vein blood samples from stroke patients were collected after fasting for12hours. ELISA and turbidimetry were used to detect plasma homocysteine, D-dimer, fibrinogen, blood lipid levels and four items of blood coagulation time. Telephone follow-up which sustained12months were used in discharged patients or their families every90days according to basic signs and symptoms. Stroke impairment assessment was applied to appraise prognosis of each patients.Results1. After intervention, the average level of plasma homocysteine was decreased by3.25umol/L in intervention group, and by1.52μmol/L in control group. Compared with control group, the level of plasma homocysteine was significantly decreased after intervention (P<0.05). The intervention group has better effect than control group.2. Compared with control group, the levels of serum lipid (D-D, TC, TQ LDL-C and FIB) were significantly decreased after intervention (P<0.05).3. Compared with control group, there were no significance in four coagulation (PT, INR, APTT and TT) levels before and after intervention (P>0.05).4. Recurrence rate in intervention group is significantly lower than it in the control group (P<0.05).5. The mean SIAS score in intervention group is (20.72±2.33) which was significantly higher than that in the control group (12.70+1.77)(P<0.01). Score in both groups was greater than10.ConclusionHyperhomocysteinemia is an independent risk factor of stroke. The plasma homocysteine levels in stroke patients decreased significantly after add folic acid and compound vitamin B. Adding folic acid and compound vitamin B can also decrease the recurrence of stroke and significantly improve the quality of life. The mechenisim might relate to the levels of D-D, FIB, TC, TG and LDL-C of stoke patients.