| Background:With the participation of the body’s immune system, AR (Allergic Rhinitis)is a chronic nasal mucosa inflammatory disease after the specific individual are exposed to allergens. It falls under the category of "bi qiu" in TCM. According to the latest figures, the incidence of this disease is about40%in children,10%-30%in adults, that’s mean there is about400million people with the disease. By the calculation, the incidence will reach50%.This will bring extremely negative influence on the health and economic development of countries around the world. At present, western medicine in treat AR have so many problems,such as many side effects,unperfected long-term curative effect. The problem of the immune agents too single treatment time too long,and allergic reaction due to the immune therapy. Comparatively,with a long history of treatment in this disease, the Acupuncture has the following advantages: easy operating, no side effect, and good curative effect. We found that the research about the warm acupuncture therapy in the treatment of AR is less, especially in the immunity function, the research is lesser. So we hope that we can evaluate the curative effect of the wann acupuncture therapy in the treatment of AR by this study, at the same time, to explore the effect in immune mechanisms.Objective:1.Further clear the curative effect of warm acupuncture in the treatment of AR, by comparing the change of the clinic symptoms and the sleep quality before and after treatment.2. To explore the action mechanism of this treatment in AR, by observing the change of IgE and EO in the blood serum before and after treatment. In order to seek strong scientific evidence for this treatment in AR, and provide new ideas and methods for the treatment in AR.Method: All the patients were from the Acupuncture and Moxibustion Hospital,from3th,2013to12th,2013. There were70patients accepted in the study according to the Inclusion criteria and assigned into two groups randomly--treatment group and control group--as the randomize scheme from computer. There were35cases in every group. The treatment group with warm acupuncture treatment,the control group with electric acupuncture treatment. The Signs and symptoms scale, PSQI(Pittsburgh Sleep Quality lndex),and the immunity index that related to AR are all as the endpoint criteria. We evaluate the clinical curative effect at the ending of the treatment, and the ending of1,3months after the treatment course had finished.Results:Totally70cases in two groups,5cases were dropped out,5eliminated. Another60cases all accomplished the therapy in plan, with no serious adverse events occurred. After the treatment course had finished, all cases accomplished the follow-up at the ending of1month,30accomplished at the ending of3months. The others did not accomplish the3months follow-up due to the time limited.The Signs and symptoms scale:All the indexes of clinical symptoms and signs between before and after treating had statistical significance in both two groups(P<0.05); comparison of two groups after treating not seen the remarkable difference (P>0.05). Comparison of clinical curative effect:The total effective rate of warm acupuncture group or electric acupuncture was93.3%and90%, were not statistical significance between two groups (P>0.05).The excellent effective rate was63.3%and53.3%, warm acupuncture group was higher than control group. PSQI(Pittsburgh Sleep Quality Index):In sleep quality,between before and after treating has statistical significance in both two groups(P<0.05),comparison of two groups after treating not seen the remarkable difference (P=0.1>0.05).In sleep efficiency, between before and after treating has statistical significance in warm acupuncture group (P=0.047<0.05),has no statistical significance in electric acupuncture group (P=0.175>0.05),comparison of two groups after treating not seen the remarkable difference (P=0.1>0.05).The related immunity index:IgE, between before and after treating has statistical significance in both two groups(P<0.05),comparison of two groups after treating has statistical significance (P<0.05);EO, between before and after treating, both were a downturn, but not seen the remarkable difference (P>0.05),comparison of two groups after treating also has no statistical significance (P=0.1>0.05). Follow-up:after the treatment course had finished, at the ending of1month, the total effective rate of warm acupuncture group or electric acupuncture both were90%,has no statistical significance between two groups (P>0.05),comparing with before treating,the excellent effective rate was43.33%and30%,the warm acupuncture group was higher than the electric acupuncture group; at the ending of3months, total effective rate of warm acupuncture group or electric acupuncture was81.25%and78.57%,not seen the remarkable difference (P>0.05),the excellent effective rate were31.25%and28.57%,the warm acupuncture group was higher than the electric acupuncture group.There were no treatment-related serious adverse events be occurred,no unusual vital signs during the course of therapy. It means that this therapy of warm acupuncture to treat AR is safe.Conclusion:(l)The therapy of warm acupuncture to treat the AR could effectively improve the clinical symptoms and signs after10treatments (about3weeks),at the same time it could improve their sleep quality.There has better long-term effects,and the excellent effective rate of warm acupuncture therapy is higher than electric acupuncture therapy.(2) The warm acupuncture therapy could reduce the level of IgE in the blood serum then inhibit the occurrence and development of allergy.(3) The therapy of warm acupuncture to treat AR is safe. |
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