Functional Dyspepsia Rats Gastrointestinal Motility And MTL、CCK Effects Of Moxibustion Zusanli

Object:functional dyspepsia (FD) rats as experimental subjects discussed FD rats gastrointestinal motility, electrogastrogram (EGG) and motilin (MTL), cholecystokinin (CCK) effects of moxibustion zusanli.Methods:48SD rats were randomly divided into four groups of12:A normal group (control group), B model group (FD model group), C moxibustion group (moxibustion Zusanli+model group), D. domperidone group (domperidone+model group). In addition to A group of normal feeding, the other3groups were pinching the tail stimulation modeling, continuous7d; After model, rats moxibustion group bundled bound30min/d and Zusanli moxibustion treatment,to the other three groups of rats bundled bound30min/d, continuous10d; domperidone group domperidone suspension1ml/100g/d by gavage, according to the other three groups of rats were gavage the same dose of saline, continuous10d. After treatment, four groups of rats ban water fasting24h, use MP150WSW-multi-channel physiological signal recording and analyzing system rats were measured fasting EGG, recording30min, do gastrointestinal motility test, in serum by enzyme-linked immunosorbent assay MTL、CCK.Result:1. After model,The control group of rats before the general state consistent with modeling, while other groups of rats modeling showed yellow hair roots withered, reduced activity, get together even lassitude, depression, stool pond. Compared with the control group of rats, and the remaining three groups of rats modeling decreased appetite, weight increase slowly after modeling, the differences were statistically significant (P<0.01). 2. After treatment, compared with the control group, gastric remnant rate model group was significantly higher, intestinal propulsive rate decreased, the differences were statistically significant (P<0.01); compared with the model group, moxibustion group and domperidone group decreased gastric remnant rate, intestinal propulsive rate was significantly increased, the difference was statistically significant (P<0.01,P<0.05), between the two groups was not statistically significant (P>0.05). Compared with the control group, the main frequency model rats and the main power decreased, the differences were statistically significant (P<0.01); compared with the model group, moxibustion group and domperidone group main frequency, the main power significantly increased, the difference was statistically significant (P<0.01), between the two groups was not statistically significant (P>0.05).3. Compared with the control group, model rats MTL、CCK decreased, the differences were statistically significant (P<0.01); Compared with the model group, moxibustion group and domperidone group, MTL、CCK was significantly higher, The differences were statistically significant (P<0.01), but there was no significant difference (P>0.05).Conclusion:1. Moxibustion Zusanli can improve FD Rats the main frequency,the main power, ease of gastrointestinal motility disorders;2. Moxibustion Zusanli can improve serum FD model of gastrointestinal hormones MTL, CCK levels.