The Research On The Method Based On Three Dimensional Modeling To Evaluate The Clinical Effectiveness

Objective:To treat Type Ⅱ DPN (Diabetic Peripheral Neuropaty) patients by tonifying Qi and nourishing Yin as well as promoting blood circulation to dredge collateral internally, in conjunction with warming channel and dispersing cold together with Tongluozhitong treatment externally. To observe the improvement on clinical manifestation, change in laboratory indexes and the impact on quality of life of patients’. Ultimately, to discuss research methods to explore the clinical efficiency of TCM assessment model based on experimental results.Method:The study divided114DPN patients from five medical centres in Sichuan province randomly to2treatment groups (Treatment Group1were given traditional Chinese Medicines and Treatment Group2were given traditional Chinese Medicines as well as externally applied drugs) and Western Medicine comparison group. During the experiment, Treatment Group1falled2cases and Treatment Group2falled4cases, in total of108cases remaining. Treatment Group1used Tongluotangtai which has the effect of tonifying Qi and nourishing Yin as well as promoting blood circulation to dredge collaterals,3times a day and150ml every time. Treatment Group2not only used Tongluotangtai but also used Tangtong lotion which could take effects in warming channel and dispersing cold together with activating meridians to stop pain,once every other day. Comparison Group took oral admission of western medicine Mecobalamin,0.5mg,3times a day. The course of treatment for3groups were8weeks. To record the observation of changes in DPN patients before and after treatment on symptom, physical signs, IFG (impared fasting glucose),2-hour postprandial blood glucose, reflex grading score,128Hz tuning fork vibratory sensation detection, VPT, R-CPT index and improvement on quality of life according to SF-36assessment. To summarize the data of syndrome score, modern detection index, the score of quality of life from three groups, and translate to "syndromes Index, modern detection benchmark index and the index of quality of life". According to the Data conversion mode as "The value of qualitative indicators, initial data normalization, dimensionless index of relative dispersion index weighting ", and then constitude3-dimensions coordinate system to graph in3dimensions. The treatment effectiveness of3groups can be reflected directly in3-dimensions modeling. Then the treatment effectiveness of each group can be compared by caculating the average distance of every case from the origin point in each group.Results:The study shows the significant effective rate and overall effective rate of Treatment Group1were40%and79%respectively, those of Treatment Group2were51%and86%. For the Comparison Group, the result were19%and69%. P of the three groups’were between0.03to0.05, the differences were statistically significant. However, Treatment Group2has distinct advantages than the other two groups in terms of the improvement on patients’sympton, physical signs, blood glucose, VPT, R-OPT as well as quality of life. A3-dimensions evaluation method which combines three traditional evalutation index (syndrome score, modern detection index, the score of quality of life) is set up to assess Diabetic peripheral neuropathy.The results indicate that Treatment Group2shows better effectiveness than Treatment Group1and Comparison Group.It also shows a higher density in Treatment Group1rather than the other groups, which means a more pervasive effectiveness or simplely a random result due to individual differences.Conclusion:Tonifying Qi and nourishing Yin as well as promoting blood circulation to dredge collaterals can significally improve DPN patients’symptom, physical signs, laboratory indexes and quality of life. It can effectively prevent and cure DPN during the occurrence and development of the disease. Take Type II DPN as an example, to use three-dimensional vector principle to establish evaluation mode of TCM clinical efficacy, can reflect the effectiveness of TMC more comprehensively and reasonably, Moreoever, it highlights the advantages of traditional Chinese medicine.