Association Between APOE Genepolymorphism And The Dose For Warfarin Maintenance

Objective:This study investigated the apolipoprotein E（APOE）genotypes and allelefrequency distribution in South Anhui Han population，analysed the relationshipbetween the apolipoprotein E（APOE）gene polymorphism and the dose for warfarinmaintenance.Methods：A total of196cases with warfarin treatment in maintenance dose and100cases of healthy South Anhui Han population.The polymorphisms of APOE wasdetected using PCR-direct sequencing method.They were divided into three groups，Group ε2（ε2/ε2,ε2/ε3），group ε3(ε3/ε3)，group ε4(ε4/ε4,ε3/ε4)，respectively.The dosesfor warfarin maintenance were compared among patients with different genotype.Results：In the total of196patients，the APOE allele frequencies were：E3/E3in142cases（72.4%），E3/E4in27cases（13.8%），E2/E3in20cases（10.2%），E2/E2and E4/E4in3cases（1.53%），E2/E4in1case（0.51%）,respectively；the allelefrequencies of ε2, ε3, ε4were6.89%,84.44%,8.67%,respectively.The warfarin dose ofgroup ε3was （3.23±0.92）mg/d,slightly higher than that of group ε2（3.13±0.86mg/d）or group ε4（3.05±0.60mg/d）,but difference of the warfarin dose among the3groupsdid not statistical significance(F=0.620,P>0.05).Conclusion：This study obtained the apolipoprotein E（APOE）genotypes and allelefrequency distribution in South Anhui Han population.APOE polymorphism may be not a major genetic factor that influences the individual dose for warfarin maintenance.