Correlation Study Between Six Elements In Blood And The Development Of Gastric Cancer In Residents In The High Incidence Area Of Gastric Cancer

Objective:To detect the levels of six elements in blood of residents in the high incidence area of gastric cancer and investigate the daily eating habits explore the role in the pathogenesis of gastric cancer.Methods:From2013July to2013December, some of the local residents who live Huangyang town and Minqing county in Gansu province had received gastro scope census. The objects were diagnosed of gastric cancer through gastro scope biopsy as gastric cancer group; The objects were diagnosed of chronic atrophic gastritis as gastritis group; The objects were diagnosed of normal through gastro scope biopsy gastro scope biopsy confirmed as healthy control group. There are242people from Huangyang town and Minqin County in Gansu province enrolled in the study, including41in gastric cancer group,111in gastritis group,90were selected as healthy control group. Using the questionnaire is composed of professional and technical personnel to guide the unified design, by the investigation of specialized personnel were conducted on the survey. Collecting subject’s blood, quantitative determination the level of copper(Cu), iron(Fe), manganese(Mn), selenium(Se), zinc(Zn), sodium(Na) by atomic emission spectrometry. The data were statistically nalyzed by SAS9.3software. Using Logistic regression analyses of single factor evaluate the correlation between gastric cancer and factors such as age, gender and helicobacter pylori. Using T test compares and analyses the degree of difference between the groups, and analyses the correlation of trace elements, high salt diet and gastric cancer.Results:①Determination of trace elements among the study groups in blood:Compared the levels of Mn, Se among groups of gastric cancer and gastritis, the difference has statistical significance(t=-2.95、-2.41,P<0.05), the levels of Cu, Fe, Zn have no statistical significance between the two groups(t=1.36%0.97%0.37, P>0.05). Compared the levels of Mn, Se between groups of gastric cancer and healthy group, the difference has statistical significance(t=-2.45%2.29,P<0.05), the levels of Cu, Fe, Zn have no statistical significance between two groups(t =0.89,1.04,0.64, P>0.05). The levels of Cu, Fe, Mn, Se, Zn of gastritis group compared with health control group no significant difference(t=0.67,1.16,0.93,0.40,0.34, P>0.05).②The objects of this research included from Huangyang town and Minqin County, to compare the levels of trace elements in whole blood of the residents, the levels of Cu, Mn, Se had statistical significance difference(t=-1.35、-1.59、-2.76,P<0.05); the levels of Fe, Zn had no statistically significant difference between the two groups(t=2.10,0.56, P>0.05).③Determining the contents of Na value in whole blood:Compared the level of Na element among groups of gastric cancer, gastritis and healthy group, the difference has no statistical significance(t=0.93、0.61、0.42, P>0.05). In the object of this study from Huangyang town and Minqin County, to compare the Na element level of the residents there was no significant difference in blood(t=0.30, P>0.05).Conclusion:Compared to the three group, including gastric cancer group, gastritis group and healthy control group, the content of trace elements in whole blood have significantly changes, there are significant difference of the content of trace elements in different parts of the residents who live in the high incidence area of gastric cancer. The research object of Na in the blood of element levels in each study no significant differences between the groups and no significant difference the Na content in the blood of different local populations. In a word, eating habits will affect the contents of trace elements in body and trace element metabolism will play an important role in the development of gastric cancer.