Clinical Curative Effect Observation Of Xinkeshu Capsule With Nifedipine For Hypertension (Qi Stagnation And Blood Stasis)

Objective：Observe the clinical curative effect and security of Xinkeshu capsulewith Nifedipine for Hypertension(qi stagnation and blood stasis)and explore themechanism of action.Methods：1. select60patients with Hypertension which are accord with researchstandard. Divide equally into treatment group and control group by random numbertable method. The patients in control group will take orally Nifedipine(ExtendedRelease Nifedipine Ⅱ tablets)(20mg, bid)everyday. In the treatment group, thepatients will take orally Nifedipine and Xinkeshu capsule (1.24g,tid). Four weeks is acourse of treatment.2.Observe the following items before and after the treatment:Changes in blood pressure、Blood pressure effects、Clinical symptoms integral、Totalefficiency、Serum Hs-CRP. The data will be compared among groups using thesoftware SPSS13.0and will analyze the correlation.Results：1. Changes in blood pressure comparing the diastolic pressure and systolicpressure of patients in two groups before treatment, we got p>0.05, the difference hasno statistical significance and it has comparability. After treatment, the bloodpressure(diastolic pressure and systolic pressure)of patients in two groups droppedobviously, especially the treatment group. Compared with the control group,p<0.05, ithas statistically difference. So we got the conclusion that the treatment group is betterthan the control group.2. Blood pressure effects There are30patients in treatment group. Thetreatment shows markedly therapeutic effect on22patients and has therapeutic effecton2patients and has no therapeutic effect on6patients. The total effective rate is80%;there are30patients in control group. The treatment shows markedly therapeuticeffect on12patients and has therapeutic effect on4patients and has no therapeuticeffect on14patients. The total effective rate is53.33%;comparing the total effectiverate of the two groups, we got P<0.05(which has statistical significance). So,theconclusion is the total effective rate of treatment group is better than the controlgroup.3. Clinical symptoms integral comparing the Clinical symptoms integral ofpatients in two groups before treatment, we got p>0.05, the difference has nostatistical significance and it has comparability. After treatment,the Clinical symptomsintegral of patients in two groups dropped obviously, especially the treatment group, Compared with the control group, p<0.01, it has obviously difference. So we got theconclusion that the treatment group is better than the control group.4. Total efficiency There are30patients in treatment group. The treatmentshows markedly therapeutic effect on20patients and has therapeutic effect on8patients and has no therapeutic effect on2patients. The total effective rate is93.33%;There are30patients in control group. The treatment shows markedlytherapeutic effect on10patients and has therapeutic effect on11patients and has notherapeutic effect on9patients. The total effective rate is70%; comparing the totaleffective rate of the two groups,we got P<0.05(which has statistical significance).So,the conclusion is the total effective rate of treatment group is better than thecontrol group.5. Serum Hs-CRP comparing the Serum Hs-CRP of patients in two groupsbefore treatment, we got p>0.05,the difference has no statistical significance and ithas comparability. After treatment, the Serum Hs-CRP of patients in two groupsdropped obviously, especially the treatment group. Compared with the control group,p<0.05, it has statistically difference. So we got the conclusion that the treatmentgroup is better than the control group.Conclusion：Xinkeshu capsule with Nifedipine has a good therapeutic effect forHypertension (qi stagnation and blood stasis) and is worth spreading.