Chronic Atrophic Gastritis In TCM Microcosmic Syndrome Differentiation And Distirbution Rules Of Canceration Tendency Analysis

Objective:For TCM microcosmic syndrome differentiation typing by mirror onpatients with chronic atrophic gastritis, and combined with confocalendomicroscopy,Helicobacter pylori detection，location of lesion biopsy, explore chronicatrophic gastritis in TCM dialectical type tendency micro distribution and carcinogenesis,and provide objective basis for clinical screening of early gastric cancer, rich withintegrated traditional and Western medicine the content, to better guide clinical medication.Methods:Painless gastroscopy for patients and confocal endomicroscopy, accordingto confocal endomicroscopy diagnosis and pathological examination results will be chronicatrophic gastritis patients, according to the internal image of all the patients were dividedinto the type of deficiency of stomach yin, stomach and blood stasis type, spleen andstomach deficiency cold type, damp heat of spleen and stomach type, liver qi stagnationtype and stagnated heat of liver and stomach syndrome type six. Based on confocalendomicroscopy examination results on the positive part of the targeted biopsy, parallelinspection and rapid urease test, pathological examination, CD34immunohistochemistryand Ki67immune group, statistical analysis of the distribution of TCM microcosmicsyndrome differentiation syndromes and canceration tendency.Results:1, Microcosmic syndrome differentiation typing of TCM syndromes:deficiency of stomach yin, the most common type accounted for31.8%, followed by thespleen deficiency type accounted for16.5%, spleen stomach damp heat type at leastaccounted for9.4%, the rest of the syndrome of liver qi stagnation accounted for15.3%,stomach and blood stasis type accounted for14.1%, stagnated heat of liver and stomach type to12.9%.2、The syndromes of TCM microcosmic syndrome differentiation between Hpinfection rate had no difference (P>0.05). Various types of intestinal metaplasia incidencehas significant difference (P<0.05), spleen stomach damp heat type intestinal epithelium ofthe card type metaplasia rate accounted for88%, followed by the stagnation of liver qistagnation type accounted for81%. TCM syndromes among the low grade intraepithelialneoplasia was significantly different (P<0.05), liver qi stagnation syndromes inintraepithelial neoplasia highest accounted for69.2%, followed by the spleen and stomachdamp heat type accounted for62.5%. Various types of CD34and Ki67immunohistochemical test were significantly different (P<0.01), the stagnation of liver qiand spleen stomach damp heat type positive expression was significantly higher than othersyndromes.Conclusion:1，No correlation between TCM microcosmic syndrome distribution ofHelicobacter pylori and chronic atrophic gastritis of infection, which may be the reason forHP are often parasitic cavity in the gastric pits and glands, the study cases, intestinalmetaplasia rate reached59%, HP lost parasitic environment,therefore, the positive rate ofHP.2,TCM microcosmic syndrome differentiation typing empirical than the deficiency,deficiency of empirical accounted for52%, accounted for48%.3,Spleen stomach dampheat and stagnation of liver qi stagnation type of intestinal metaplasia detectable rate,intraepithelial neoplasia detection rate and immunohistochemistry to examine theexpression levels were higher than other syndromes.