Experimental Study On The Platycodin Bcl-2in Breast Cancer Tissue Factor

Purpose: with an experimengtal animal model of breast cancer to evaluate the therapeutic effect of platycodin breast cancer; through differences between the comparison group content of breast tumors in rabbits Bcl-2factor clarify its mechanism of action, provide a new way to treat breast cancer.Methods:1.through the already very mature VX2tumor tissue suspension farming, manufacturing rabbit model of breast cancer.2kinds of about one week after the tumor mass may form a substantial part of2-3weeks after the animals can be touchedslightly swollen underarm lymph nodes, tumor measuring rabbits in each group diameter(a) and short axis(b) tumor volume was calculated(V).V=a b2/2,the inhibition rate were calculated banzhilian platycodin group and the group, the inhibition rate formula: inhibition rate=(control group, the experimental group V-V)/control V x100%.Breast tumor tissue from rabbit,withBcl-2enzyme-linked reaction kit to detect theexpression of breast tissue in rabbits Bcl-2protein. Discussion platycodin group, banzhilian group inhibition of breast cancer breast cancer cells in rabbits;Results:1.compared with the model group, the group and the positive banzhilianplatycodin tumor volume in the control group were decreased(P <0.05),compared withthe content of the model2.Platycodin rabbits breast tissue factorBCL-2group was significantly lower compared to the expression(P <0.05),indicates that the mechanism of tumor suppression Platycodin could make by reducing the expression of Bcl-2factor, reducing the number of synthetic Bcl-2in breast cancer tissue factor, thereby blocking its tumor cells affect the normal apoptosis process.3,compared with banzhilian group Platycodin tumor inhibition index higher than the model group(P <0.05)Conclusion:Platycodin significantly reduced tumor growth in breast cancer model in rabbits. Platycodin can inhibit tumor cell growth rate, preventing further deterioration. Platycodin content can reduce BCL2-factor rabbit adenocarcinoma, indicating Platycodin reduce the expression of Bcl-2may be a factor interms of its mechanism ofinhibition of tumor growth compared Platycodin group by group with barbata tumor volume inhibition rate between the two groups and were significantly different(P <0.05),indicating that the treatment effect on breast cancer than banzhilian platycodin water extract solution.