Epidemiological Analysis Of The Causes Of 338 Patients With Breast Cancers

Objective:To analyze the pathological and clinical data of 338 patients with breast cancer,especially the characteristics of breast cancer and the dynamic changes of the endocrinotherapy and the molecular targeted therapy. The results was expected to provide a basis for the etiology and treatment of breast cancer.Methods:The data of 338 cases of breast cancer were collected from 2010 to 2014 a hospital.The 338 cases were confirmed by the two pathologist. The demographic(age, sex,occupation et al.) and the clinical information, including the tumor site, pathological type, staging, operation way, lymph node metastasis and the expression characteristics and dynamic changes of ER, PR, Ki-67, Cerb B-2 were collected and istical analyzed.Results:338 cases of breast cancer, include 5 men and 333 women. The median age of the patients was 45, and the youngest was 23 years old, the oldest was 84. A total of 233 cases were between 41 and 59 years old, accounting for 66.8%. Breast cancer was gradually younger age in five years and the incidence was increased year by year.Invasive ductal carcinoma was the most common pathological type, a total of 188 cases(55.6%). 257 cases(76%) were Stage II(the most common pathologic types) in PTNM staging. The most surgery way of breast cancer was modified radical mastectomy. But the surgery way of breast cancer was changed from modified radical mastectomy to lumpectomy and axillary dissection. It showed that ER and PR were weakly expressed in the lymph node metastasis of breast cancer cases, while the expression of Ki-67 and Cerb B-2 were higher significantly(P<0.05). The greater the rate of tumor, the lowerexpression of ER and PR, while the higher expression of Ki-67 and CerbB-2(P<0.05).The expression of ER, PR and Cerb B-2, Ki-67 was negatively correlated. It was expected to provide a basis for the treatment of breast cancer.Conclusion:The onset age of breast cancer was younger and its incidence was increased year by year. The peak age of breast cancer was 41 to 59 years old. The most common site of the breast cancer is the upper outer quadrant. Invasive ductal carcinoma was the most common pathological type and the highest lymph node metastasis rate. Stage II was the most common pathologic types in PTNM staging. The most surgery way of breast cancer was modified radical mastectomy, while changing to lumpectomy and axillary dissection.The expression of ER, PR and Cerb B-2, Ki-67 was negatively correlated, which provided a new basis for the treatment of breast cancer.