Correlation LRRK2 Gene R1628P Mutation And Parkinson’s Disease In Xinjiang

Objective:Study of LRRK2 r1628p site mutation and in Xinjiang Uygur and Han population of Parkinson’s disease, Parkinson’s disease (PD) in the pathogenesis, clear two peoples in the distribution on the existence of differences of mutant LRRK2 r1628p gene locus. Methods:a case control study on the selection of clinical diagnosis of PD were as case group of 281 people (170 cases of Han, Uygur 111 cases), healthy persons for control group 330 (160 cases of Han, Uygur 170 cases), using polymerase chain reaction restriction fragment length polymorphism of (polymerase chain reaction fragment length polymorphism, PCR-RFLP and DNA sequencing method in Xinjiang Uygur and Han populations in the LRRK2 r1628p gene locus mutation analysis. Results:in Xinjiang Uygur and Han nationality in PD patients and control group LRRK2 r1628p site by restriction enzyme found only GG genotype, no GC and CC type of mutation, by sequencing and enzyme cut results consistent, were not detected in the LRRK2 r1628p gene mutation of GC and CC type; the mutation frequencies were 0. There was no statistically significant difference. There was no significant difference in the genotype and allele frequencies of LRRK2 gene between Uygur and Han PD group and the normal control group (P>0.05), R1628P. Uygur PD and Uighur control between LRRK2 r1628p gene locus genotype and allele frequency, the difference was not statistically significant (P>0.05). There was no significant difference in the genotype and allele frequencies between the R1628P and the allele frequencies between the LRRK2 and the Han nationality PD controls (P>0.05). Uighur PD and PD in Han group between LRRK2 r1628p gene locus and allele frequency, the difference was not statistically significant (P> 0.05). There was no significant difference in the genotype and allele frequencies between the LRRK2 and R1628P alleles between the EOPD and LOPD groups (P>0.05). There was no significant difference in the genotype and allele frequency between male PD and female PD group LRRK2 R1628P (P>0.05). The results showed that the distribution of the mutations of the R1628P gene in the different nationality, age and sex of the LRRK2 gene was not statistically significant (P>0.05). Conclusion:(1) The LRRK2 rl628p gene locus in the study of genotype GG genotype, no GC type and CC and GG genotype frequency was 100%, the GC genotype frequency was 0%, the frequency of genotype CC was 0%, carrying the G allele frequency was 100%, allele C frequency was 0. (2) In the Xinjiang region, the R1628P locus of the LRRK2 gene in the Uygur nationality and Han nationality, the PD gene, has no genotype and allele mutation.