Rupi Decoction In The Treatment Of Breast Hyperplasia (The Type Of Qi Stagnancy In Liver) Clinical Observation

Objective:By observing the changes of breast pain,breast lumps,TCM syndrome and the changes in hormone, evaluation of Rupi Decoction in the treatment of hyperplasia of mammary glands (stagnation of liver qi stagnation syndrome) of effectiveness and safety.Methods:In this study, randomized method,The subjects were 60 cases of 30 cases were randomly divided into experimental group and a control group of 30 cases.Experimental groups:30 patients in each group, according to the menstrual cycle are serving two months taking 48 days,21 days of medication each menstrual cycle, menstrual withdrawal,Rukang decoction:Rupi decoction one, sooner or later each half. After the first month of taking 21 days menstrual cycle withdrawal, the second menstrual cycle to continue taking 21 days, the withdrawal period,The total course of treatment for two months,Control group:Rukang tablets 1/0.3g, and 3, the first 21 days of taking the menstrual cyclemenstrual withdrawal, second menstrual cycles continue to take 21 days, menstrual withdrawal, the total course of treatment for two months.Before taking the menstrual cycle written informed consent form to sign and general inspection,(Height, weight, blood pressure, heart rate, etc).Before taking it three days before menstruation breast ultrasound check,Blood, urine, liver and kidney function,estrogen,progestero ne,After taking 21 days of menstruation,After next month after 21 days of medication.After two courses of three days before menstruation review the double breast ultrasound, blood, urine, liver and kidney function, estrogen and progesterone.Then according to breast pain scores, changes in breast tumor size, estrogen levels, TCM symptom scores before and after treatment, evaluation Rukang decoction (The type of Qi stagnancy in liver) hyperplasia efficacy and safety.Results:1.Rupi Decoction in the treatment of breast hyperplasia pain, comparison of P<0.05 before and after treatment in experimental group and control group before and after P<0.05. The experimental group compared with the control group after treatment:P=0.38, P>0.05 no difference between the two groups.2.Rupi Decoction in the treatment of hyperplasia of mammary gland tumor (size and hardness), the experimental group before and after treatment, P< 0.05) and the control group before and after the comparative (P< 0.05). The experimental group compared with the control group after treatment: P>0.05 no difference between the two groups.3.Rupi Decoction in the treatment of breast hyperplasia of TCM syndrome (chest tightness, chest pain, etc.), the experimental group before and after treatment, P< 0.05) and the control group before and after the comparative (P < 0.05). The experimental groupcompared with the control group after treatment P=0.01, P<0.05 there are differences between the two groups.4.The total effect of Rupi Decoction in the treatment of breast hyperplasia, comparison of P<0.05 before and after treatment in experimental group, the control group before and afterP<0.05. The experimental group compared with the control group after treatment P=0.01,P>0.05 had no difference between the two groups. The two group total effective rate of treatment group 96%, control group 89%. In the experimental group than those in the control group.5.Rupi Decoction on estrogen and progesterone, comparison of P<0.05 before and after treatment in experimental group and control group before and after P<0.05. The experimental group and the control group after treatment P>0.05 had no difference between the two groups.6. The security check, blood routine, urine routine, liver function, renal function, in the normal range, before and after treatment, no difference, no adverse reaction.Conclusions:1.Rupi Decoction in the treatment of breast hyperplasia can effectively relieve pain, with no difference between the treatment effect of Rukang tablet.2.Breast masses Rupi Decoction in the treatment of breast hyperplasia disease can effectively reduce and enable the mass of lower hardness, no differences with the Rukang tablets in the treatment effect.3.Rupi Decoction in the treatment of breast hyperplasia can effectively alleviate the symptoms of traditional Chinese medicine, the treatment effect is better than that of rukangtablet.4.Rupi Decoction in the treatment of breast hyperplasia overall curative effect is better than that of rukangtablet.5.Rupi decoction can reduce estrogen and progesterone increased breastcare effect is no difference.6.Clinical application of Rupi decoction is safe, safety indicators before and after treatmentshowed no abnormalities, no adverse reactions.