Observe The Simple Obesity Treatment Efficacy Of The Peilianmahuang-Fang And Research On Its Effects On The INS、GLP-1 And IAPP

Objective:Explore peilianmahuang-fang clinical efficacy on simple obesity by observating peilianmahuang-fang treatment of simple obesity and its effect on INS, GLP-1, IAPP.Subjects and Methods:The 64 cases of simple obesity patients are randomly divided into two groups, which are treatment group and control group, and 32 cases are in each group. The treatment group receives basic treatment combined with peilianmahuang-fang, the control group receives basic treatment including health education, appropriate exercise, diet control and behavior intervention. The experiment results of the two groups above are observed after treatment which are clinical sign, TCM symptom score, body weight, BMI, WHR, lipid profile (TC、TG、LDL-C), INS、GLP-1 and IAPP.Results:1. In the aspect of symptoms and signs improvement and traditional Chinese medicine symptoms, the efficacy are compared between two groups. As a result that its efficiency and TCM symptom scores are significantly different (P<0.05). The results demonstrate that the peilianmahuang-fang can improve symptoms and signs and syndromes.2. Two groups indicators of body weight, BMI, WHR are compared before and after treatment within the group, P<0.05 are significantly different, and these three indicators are compared after treatment between for three indicators comparison between treatment group and control group, P<0.05 are significantly different. As a result, the treatment group has a better efficacy than the control group in losing weight.3. In the lipid aspect, the TG values of the treatment group are compared before and after treatment, P<0.05 are significantly different, After that, the TG values after treatment of the treatment group are compared with the TG values after treatment of the control group, P<0.05 are significantly different. The comparison results show that has a great effect on treatment group in TG improvement. The peilianmahuang-fang also has a certain effect on TC and LDL-C improvement, but P>0.05 are not significantly different.4. In the aspect of improvement insulin levels, the results are compared between the treatment group and the control group, P<0.05, the conclusion can be drawn that the treatment group has more significant effect on decreasing insulin levels and improving insulin resistance than the control group. In the aspect of IAPP and GLP-1 improvement, the result of the treatment group before and after treatment is P<0.05, which is significant difference. The result shows that the treatment has a significant effect on the decreasing the GLP-1 levels, promoting IAPP secretion. Another aspect is that the comparison results of the control group is P>0.05, which shows that the efficacy is not significantly different.Conclusions:1.Use peilianmahuang-fang to treat dampness simple obesity can significantly reduce body weight, significantly reduced values of BMI, WHR, and decrease the TG levels.2.Peilianmahuang-fang is able to reduce the resistance in obese subjects stomach wet type of symptom scores, improved clinical symptoms and signs.3.Peilianmahuang-fang can reduce insulin and IAPP levels, promote the secretion of GLP-1, so the efficacy of inhibiting appetite, delaying gastric empty and reducing the body weight can be achieved by relieving insulin and IAPP resistance, promoting the secretion of GLP-1.