Clinic And Mechanism Research Of Xinjunxiaogao Fang On Simple Obesity

With the economic development and improvement of living condition, obesity has become a troubling issue in public health and affects the living quality of obese patients a lot. It is an important for our country even global medical circle to study the pathogenesis of the obesity and prevent and cure the disease early and effectively. The content of the research is as follows.ObjectiveTo observe the clinical effect and safety of XinjunxiaogaoFang in treating simple obesity and to discuss the function mechanism of the influence on resistance of Leptin and IR.Method100 cases of simple obesity were divided into two groups randemly. The treatment group had 47cases, treated with XinjunxiaogaoFang, the control group had 53cases, treated with 10% concentration of XinjunxiaogaoFang. The treatment course of each group is 24 weeks. We observed the change of clinical symptom, TCM syndrome, waist, waist-hip ratio, weight and body mass index, general CHO, TG, LDL HDL, before and after treatment. To discuss the function mechanism of the influence on resistance of Leptin and IR, we measured the serum Leptin, Insulin, TNF-a, IL-6 and SOCS3 before and after treatments, and then calculated the HOMA-IR.We use t test, Pearson Correlation analysis and other statistical methods to determine he differences and the relevance of statistics.ResultsAfter the treatment of one course, body weight,BMI, waist circumference and waist-hip ratio are decreased The therapy effect is better for the male. There was no statistical difference of the therapy effect between the moderate obesity and severe obesity. There was no difference of the therapy effect between the different age groups. We also found there is significant difference in the clinical symptom, TCM syndrome before and after treatment. There is no obvious difference in he target values of TG?TC?and LDL, only HDL is increased after treatment. The data indicated that acupuncture could correct the resistance of Leptin and IR. Fasting blood serum concentrations of TNF-a and SOCS3 were lower, and they were both correlated with Leptin.ConclusionXinjunxiaogaoFang could lower body weight,BMI,waist circumference and waist-hip ratio, and improve the symptoms and HDL. It could correct IR and LEP resistance also. The result that TNF-a and SOCS3 were decreased after the treatment showed XinjunxiaogaoFang can reduced chronic inflammation which may be one of the mechanism to improve the insulin resistance.