Clinical Observation Of Peilianmahuangfang Addition In Treating Simple Obesity With IGT (Stomach Heat Stagnation Type)

Objective:This subject compares the changes of TCM syndrome scores and signs before and after treatment in two groups of patients,and monitors the changes of body weight,blood sugar,blood lipids and other indicators to observe the clinical efficacy of Peilianmahuang Fang addition in the treatment of simple obesity with IGT stomach heat spleen syndrome.Methods:A total of 60 patients with outpatient diagnosis of simple obesity with IGT in the outpatient clinic of Heilongjiang University of Traditional Chinese Medicine were selected,and the syndrome differentiation of TCM accorded with the syndrome of gastric heat stagnation and spleen syndrome was randomly divided into a treatment group(n = 30)and a control group(n = 30),the control group was given basic treatments such as diet control and reasonable exercise.The treatment group was given Peilianmahuang Fang addition treatment on the basis of the control group,and both groups were treated continuously for 8 weeks.Compare the changes in body weight,BMI,WC,FPG,2h PG,TC,TG,LDL-C,FINS,HOMA-IR,etc.and the improvement of TCM syndrome points before treatment,4 weeks of treatment,and 8 weeks of treatment,and observe the safety indicators during treatment.Result:1.After 8 weeks of continuous treatment,the total effective rate of the two groups was compared.The treatment group was 90.00% and the control group was 63.33%.The treatment group was significantly better than the control group(P <0.05).2.After 8 weeks of continuous treatment,the total scores of TCM syndromes in both groups decreased(P <0.05),and the total scores in the treatment group improved more significantly compared with the control group(P <0.05).3.After 8 weeks of continuous treatment,the body weight,BMI,and WCof the two groups were significantly lower than before treatment(P <0.05).Compared with the control group,the weight-related indicators of the treatment group were significantly improved(P <0.05).4.After 8 weeks of continuous treatment,the 2h PG serum level of the two groups decreased(P <0.05).Compared with the control group,the 2h PG level of the treatment group improved more significantly(P <0.05);FINS serum levels and HOMA-IR decreased(P <0.05).Compared with the control group,FINS serum levels and HOMA-IR improved more significantly in the treatment group(P <0.05).5.After 8 weeks of continuous treatment,the TC and TG serum levels of the two groups decreased(P <0.05).Compared with the control group,the TC and TG levels of the treatment group decreased more significantly(P <0.05).6.After 8 weeks of continuous treatment,there were no serious adverse drug reactions and abnormal safety indicators in both groups.Only one female patient in the treatment group had mild menstrual symptoms during menstruation,but did not affect the normal medication and treatment.In conclusion:1.Peilianmahuang Fang addition can reduce the TCM syndrome score of patients with simple obesity accompanied by IGT(stomach-heat stagnation syndrome),and effectively improve the clinical symptoms and signs of TCM.2.Peilianmahuang Fang addition can reduce the weight of patients,regulate disorders of glucose and lipid metabolism,and also have a therapeutic effect on insulin resistance.3.Peilianmahuang Fang addition has better safety in this clinical application.