Interleukin-17 Expresses In Serum And Saliva Of Kazak Patients With Type 2 Diabetes And Chronic Periodontitis And Correlation Studies

Objective: The objective of the current study was to investigate the relationship of type II diabetes mallitus with chronic periodontistis by analyzing the expression of interlukin-17 in the serum and saliva of Kazak patients who were diagnosed with both diseases. Methods: The study sample was comprised of 200 patients out of which 60 cases were simple chronic periodontitis, 40 cases of simple type II diabetes mellitus, 40 cases were type II diabetes mellitus along with chronic periodontitis and 60 cases of healthy individuals were included as a control group. Clinical periodontal examination index, fasting blood glucose(FBG) level, stimulated saliva and blood samples of each individual were collected. Antibody sandwich ELISA technique was incorporated in this study to determine the concentrations of interlukin-17 and-6. Results: Periodontal clinical indicators such as probing depth(PD), clinical attachment loss(AL) and number of missing teeth along with serum and saliva concentrations of interlukin-17 showed statistically significant(p<0.05) differences between periodontitis + diabetes(P+D) group, simple diabetes(D) and simple periodontitis group(P). Group P+D showed highly positive correlation(p<0.05) between AL and FBG, AL and saliva IL-17, sputum IL-6 and IL-17. The latter two were higher in P+D group than in group P. Conclusion: In Kazak patients’ type II diabetes is found to be associated with the increased degree of pathological changes involved in chronic periodontitis. Interlukin-17 is may be an important chemical mediator which is found to be associated with both diseases. The exact mechanism of its action is need to be explored in future.