| Background:Methamphetamine has a strong central stimulant Action, which as a kind of new drugs, Methamphetamine abuse can form drug dependence, produce psychotic symptoms, and then leading to mental disorders. The numbers of new illicit drugs abuse is rapid increasing today, however there has been rare research related to amphetamine type drugs abusers combining psychotic symptoms, which of the pathogenesis are not clear so far. Consequently, to explore the pathogenesis of mental disorders induced by this type drugs is significant important to it’s prevention and treatment.Objective:1 To identify the impulsive aggressive personality of the methamphetamine abuser.2 To explore the correlation between methamphetamine abusers and the serum concentrations of BDNF.3 To understand the relationship between methamphetamine abusers and their BNDF G196A gene polymorphism.4 To identify the relationship between BDNF G196A gene polymorphism of methamphetamine abusers and their serum concentrations of BDNF.Method:1 Participants Two hundred and thirty three inpatients were screened for this study, who were being treated at a drug rehabilitation center in AnKang Hospital of Shandong Province from August 2012 to October 2013. All of the inpatients were met the criterion of psychoactive substance induced-psychosis in the Diagnostic and statistical manual of mental disorder-Ⅳ(DSM-Ⅳ).The cases group was divided into two groups according to whether with or without psychotic symptoms, one group is named the methamphetamine abusers without psychotic symptoms group, which has 171 cases; the other was named the methamphetamine abuse group, which has 62 cases. The healthy volunteers of control group were recruited through a factory worker with no history of drug abuse, which has a total number of 110 cases.2 Scale measure Basic information questionnaire were administrated to all subjects, and they were assessed with Barratt Impulsivity Scale(BIS) and Barratt Aggressive Scale(BAS) to respectively evaluate the psychiatric symptoms of patients and impulsive aggressive personality trait.3 Blood measure The serum concentrations of BDNF were measured by Enzyme-Linked immunosorbent Assay (ELISA), the polymorphisms of BDNF G196A gene were detected by PCR-DNA sequencing.4 Statistics All the data were analyzed by SPSS 16.0 software. Analysis of all indexes before Levene of test. Data for the measurement data mean and standard deviation of the normal distribution represented by M and SD. The comparing between the two groups were conducted by the t-test for independent samples, or nonparametric tests. Comparison of among 3 groups were conducted by the way of one-way analysis of variance(one-way ANOVA). Count data using the chi-square test to estimate whether the distribution of the genotype identified by Hardy-Weinberg law genetic equilibrium and compare two genotypes. P<0.05 was considered to be statistically significant.Results:1 The BIS total scores, planned impulse, physical impulse and cognitive behavior impulse scores of the inpatients group were higher than the control group (P<0.05); The BAS total scores, verbal aggression, anger and self attack scores of the patients group were higher than the control group (P<0.05).2 The serum concentrations of BDNF in case group (205.81±75.36) pg/ml were significantly higher than those in control group (95.04±31.63) pg/ml (t=15.02,P <0.01), there was no significant difference about the BDNF serum concentrations between the inpatients with the amphetamine induced psychosis and the inpatients with the amphetamine abuse (P>0.05)3 There was no significant difference in BDNF G196A genotype among three groups (P>0.05), as well as the frequency of alleles (P>0.05)4 The BDNF serum concentration has no significant difference in the genotype distributions and allele frequencies (P> 0.05)Conclusion:1 The patients with the amphetamine induced psychosis have obvious impulsive aggressive personality.2 The serum concentrations of BDNF was significant correlated with amphetamine abuse, and there was no obvious correlation between methamphetamine abusers with psychotic symptoms and without psychotic symptoms.3 BDNF G196A gene type have no relationship with the methamphetamine abusers,the BDNF G196A gene locus may not be a risk factor in methamphetamine abuse.4 The serum concentrations of BDNF has no correlation with BDNF G196A gene polymorphism. |
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