Study On The Relationship Between Serum Osteocalcin Levels And Atherosclerosis In Type 2 Diabetic Mellitus

BackgroundAtherosclerosis is one of the common complications of type 2 diabetes, compared with non-diabetic population, the prevalence of atherosclerosis in diabetic patients was significantly higher, with younger age of onset and rapid progression. In recent years, there is growing evidence that serum osteocalcin (OC) level correlates with glucose metabolism, lipid metabolism, then perhaps between serum OC and T2DM atherosclerosis has certain relevance. Therefore, we aimed to explore the relationship between serum OC and atherosclerosis in patients with T2DM through determination of serum OC levels, blood glucose, lipid metabolism related indexes, and carotid artery intima-media thickness (C-IMT) in patients with type 2 diabetes..ObjectiveTo explore the relationship between atherosclerosis and serum osteocalcin levels in T2DM patients, in order to put forward new ideas for the prevention and treatment of atherosclerosis.Methods60 T2DM patients were recruited in this study, containing 27 male patients and 33 postmenopausal women. The C-IMT and levels of serum OC, fasting plasma glucose (FPG), fasting C peptide (FCP), triglyceride (TG), low density lipoprotein (LDL), apolipoprotein B (apoB), apolipoprotein A-1 (apoA-1) and other clinical indicators of all patients were detected. The correlation analysis was conducted between OC and C-IMT, OC and other factors. Using the C-IMT as the evaluation index of atherosclerosis.ResultsThere were significant differences between male and postmenopausal female in the serum levels of OC and C-IMT. In male patients, the age, course of disease, BMI, LDL, apoB/apoA-1 and C-IMT were positively correlated with the C-IMT mean, on the contrary, the serum OC levels were negatively correlated with C-IMT mean. In postmenopausal women, the age, course of disease, BMI, LDL, apoB/apoA-1 were positively correlated with the C-IMT mean, whereas no obvious correlation between the levels of serum OC and C-IMT mean was detected.ConclusionThe serum levels of OC are correlated with atherosclerosis in type 2 diabetic patients. OC is not just an important indicator of sugar, lipid metabolism, but may also be an independent risk factor of atherosclerosis in type 2 diabetic patients. All these suggest serum OC could be a risk assessment and monitoring index of atherosclerosis.