The Clinical Research Of Fu Fang Qi Shu Decoction Combined With Highly Active Antiretroviral Therapy Treating Aids In Type Of Spleen-insufficiency With Dampness- Overabundance

Objective:Observe the clinical effects of treating AIDS by Fu Fang Qi Shu decoction combined with highly active antiretroviral therapy (HAART).Methods:Collected 74 AIDS patients in type of insufficiency of the spleen with overabundance of dampness who met the criterion of HAART, divided them into 3 groups:group one were treated with HAART (30 patients); group two were treated with Tang Cao tablet(TC) combined with HAART (30 patients), Tang Cao tablets were taken orally,8 tablets three times one day. Group three were treated with Fu Fang Qi Shu decoction (FFQS)combined with HAART (30 patients). Fu Fang Qi Shu decoction were taken 300 ml after dinner twice a day,and granules were taken one pack twice a day.Each group were treated for 6 months. Observed the quantitative calculus on TCM symptoms,the quantity of T-cell,body weight after 3 months or 6 months, and blood routine test,hepatic and renal function,and other adverse reaction during treatment.Results:1.Quantitative calculus on TCM symptoms:Compared with baseline, the quantitative calculus on TCM symptoms of TC group and FFQS group declined after treating 3 or 6 months,the difference has statistical significance (P<0.05). Compared with HAART group, the difference in quantitative calculus of TC group and FFQS group after treating 3 or 6 months has statistical significance (P<0.05 orP<0.01). The difference between TC group and FFQS group after treating 3 or 6 months has no statistical significance (P>0.05).2.TCM syndrome effects:The total effective rate of TC group and FFQS group after treating 3 months or 6 months is higher than HAART group, the difference has statistical significance (P<0.01).Among the two group there is no statistical significance (P>0.05).3. Quantity of T-cell:Compared with baseline, the quantity of T-cell in each group after treating 3 months or 6 months has statistical significance (P<0.05orP<0.01). Compared with the HAART group, the quantity of T-cell in TC group and FFQS group after treating 6 months has statistical significance (P<0.05). The difference of the quantity of T-cell after 3 months or 6 months between TC group and FFQS group has no statistical significance(P>0.05).4. Body weight:The body weight of HAART group declined after 3 or 6 month, the difference has statistical significance (P<0.05 or P<0.01).The body weight at 6 month is lower than at 3 month,and the difference has statistical significance (P<0.01).5. Security:There is no significant change in general medical examination for the body, urine routine test, feces routine test, renal function and ECG etc. The difference of abnormal quantity rate of WBC,HB and PLT between three groups has no statistical significance(P>0.05).There is also no statistical significance on ALT、AST、 TB between each group (P>0.05).Conclusion:Fu Fang Qi Shu decoction has effects in releasing he quantitative calculus on TCM symptoms enhancing the quantity of T-cell and body weight, which is more effective than using HAART only, and equivalent to Tang Cao tablet. Fu Fang Qi Shu decoction has no significant adverse effects, and confirms safe and reliable.