The Clinical Significance Of Children With Primary Nephrotic Syndrome With Immunoglobulin E Detection

Objective:To investigate the primary nephrotic syndrome of immunoglobulin E detection in clinical significance. Methods:randomly selected 61 cases of hospitalized children, children with primary nephrotic syndrome 41 cases (treatment group), the children with primary nephrotic syndrome 20 cases (control group); According to the level of immunoglobulin E to begin with the 41 cases were divided into normal group and high level group, by evaluating children before and after treatment, serum albumin urine protein levels such as clinical evaluation of immunoglobulin E levels in the clinical significance of primary nephrotic syndrome. Results:Children with primary nephrotic syndrome immunoglobulin E levels (364+200 IU/ML) is higher than the control group (63+118 IU/ML), there were significant differences (χ2=7.48, P<0.05), the allergy 18 patients in experimental group and control group in 2 cases, there are significant differences (χ2=5.56, P<0.05), suggesting the IgE is higher in experimental group; IgE level 25 cases in experimental group has a history of allergies in 15 cases,16 cases of normal IgE level 3 cases, was statistically significant (χ2=6.70, P<0.05); Experimental group 2 groups of nephrotic syndrome in children with different levels of IgE in 4 weeks after treatment hormone curative effect,25 cases with high IgE levels of hormone sensitive in 20 cases,16 cases of normal IgE levels of hormone sensitive in 15 cases, no significant differences (x2=0.58, P> 0.05); 41 cases in the experimental group,6 cases of hormone resistant type, including 25 cases of high level of IgE group had 4 cases,16 cases of normal IgE levels in 2 cases, no statistical differences in the two groups (χ2=0.064, P>0.05)relapse within 1 year,25 cases of high level of IgE group a 14 cases had a relapse,16 cases of normal IgE level 3 cases recurrence, have obvious difference (χ2=4.15, P<0.05); High levels of IgE group have 5 cases of recurrent frequency, normal IgE3 cases of recurrence, no statistical differences (χ2=0.09, P>0.05) Conclusion:Children with nephrotic syndrome than normal children with higher levels of immunoglobulin E, prompt the immune rubber bladder E may participate in the occurrence of nephrotic syndrome process; Children with high levels of immunoglobulin E prone to allergic disease; Immunoglobulin E had no significant effect on the curative effect of children with nephrotic syndrome. Children with high level of immunoglobulin E has a higher relapse tendency, may total serum immunoglobulin E levels as predict outcome of PNS.