Changes And Clinical Significance Of Serum IgE In Children With Primary Nephrotic Syndrome

Objective:Explore clinical significance of serum immunoglobulin E in children with primary nephrotic syndrome.Analyse changes of serum Ig E levels and correlative factors in children with primary nephrotic syndrome through retrospective studies,To evaluate the meaning and value of Ig E in forecasting the response of children to hormone therapy.Methods:From January 2017 to December 2019,the clinical data of children diagnosed with primary nephrotic syndrome in pediatrics of the first hospital of Shanxi Medical University were collected.A total of 50 cases were collected.Divide the children into different groups according to different clinical conditions.They are simple nephropathy group and nephritis nephropathy group,moderate proteinuria group and severe proteinuria group,hormone sensitivity group and hormone resistance group.Observation and statistical indicators for both groups include:serum immunoglobulin E(IgE),serum immunoglobulin G(IgG),serum immunoglobulin M(IgM),serum immunoglobulin A(IgA),C3,24-hour urine protein quantification(24 h urine proteinquantitation),albumin(albumin,ALB),total cholesterol(TC),and response to hormone therapy.And analyze the correlation between the IgE level and other indicators.Then combine with clinic,analyse data and arrival at a conclusion.Results:1.The IgE level(IU/mL)of the hormone sensitive group was 346.8±212.9 compared with that of the hormone resistant group 150.5±99.6.the difference between the two groups was statistically significant(p<0.01),and the difference between the remaining indexes was not statistically significant(p>0.05).2.The correlation between IgE and other indicators was analyzed,and it was found that IgE was positively correlated with IgM,and the correlation coefficient was 0.371,p<0.05.3.The two results of hormone sensitivity and hormone resistance were examined by roc curve with IgE values.It was found that the diagnosis of hormone sensitive nephrotic syndrome is optimal at 164.5IU/mL,the sensitivity was 81.1%,the specificity was 69.2%,and jorden index was 0.503.4.The urinary protein levels of simple nephropathy group were lower than that of nephritis nephropathy group in 24 hours(p<0.05),The difference of IgE and otherbiochemical standard were not statistically significant(p>0.05).5.Serum albumin and IgE in the severe proteinuria group were lower than those in the severe proteinuria group(p<0.05).IgE and the rest of biochemical standard were not statistically significant(p>0.05).Conclusion:1.The IgE level of children who were first onset and were hormone sensitivity was higher than those were first onset and were hormone resistance,and the diagnosis of hormone sensitive nephrotic syndrome is optimal at 164.5IU/mL,the sensitivity was81.1%,the specificity was 69.2%,and jorden index was 0.503.2.The IgE was positively correlated with the IgM index,and the correlation coefficient was 0.371,which was not correlated with other laboratory indexes.3.Elevated IgE levels in children with nephrotic syndrome are not as a result of atopic disease,but the disordered immune system in children with nephrotic syndrome is more likely to lead to elevated IgE levels.