Clinical Research Of High-selected Anticholinergic Gents In The Treatment Of Overactive Bladder During The Perioperative Period Of PKRP

Object:To evaluate the efficacy and safety of high-selected anticholinergic gents in the Prevention and treatment of overactive bladder(OAB) syndrome in patients who have undergone transurethral bipolar plasmakinetic resection of prostate(PKRP). Methods 102 patients who had undergone bipolar plasmakinetic resection of prostate,Were randomly divided into two groups, Each 51 cases. Experimental group using high-selected anticholinergic gents (Solifenacin Succinate Tablets) treatment, preoperative 2～3d, after 3-4d(5mg one daily),The control group did not take any Interference Bladder detrusor or other drugs. Observe and compare the two groups of patients data after catheter removed. The mean urinary urgency, Frequency of urination, nocturia, urinary incontinence, Bladder spasms, Qmax, PVR, IPSS,OABSS, PPBC, QOL and OAB remission rate were analyzed. Results The experimental group on the 24h,3th day after catheter removal, urinary urgency per day (3.59±0.21,2.72±0.89), nocturia (2.82±0.67,2.03±0.74), urge incontinence frequency (1.86± 0.52,1.69±0.77), bladder spasms (3.61±1.1,2.17±0.74), QOL score (2.68 ±1.10,2.31±0.74), IPSS score (12.71±2.44,7.84±1.79), PPBC score (3.30±1.11,2.58±0.79),OABSS score (8.55±1.69,7.20±1.79) were lower than the control group, The two groups (P<0.05), there are statistically significant.24h after removal of the catheter frequency of urination experimental group (12.80±1.79), control group (13.29±2.74) no significant difference, while on the 3th day experimental group (6.24±3.01), control group (8.21±1.77), the two groups(P<0.05), there are statistically significant. Removal of the catheter section 3d of Qmax, experimental group (19.29± 3.46), control group (20.82±5.36),There had no significant difference, And PVR experimental group (18.31±3.33) was significantly higher than the control group (16.41±3.48), The two groups (P<0.05), There are statistically significant. Overactive bladder remission rate of 2 groups (P<0.05), there was significant. Experimental group during the treatment adverse reactions occurred in 15.7% of total(8/51), But patients can be tolerated with no serious adverse events. Conclusions High-selected anticholinergic agents is effective and safe in the Prevention and treatment of OAB patients after PKRP, And should be recommended for clinical use.