A Case-control Study Of The Risk Of Parkinson’s Disease With Hypertension, Hyperuricemia And Lifestyle

Background Parkinson’s disease(PD)is a neurodegenerative disorder that mainly affects the middle-aged and elderly people. Progressiving motor dysfunction and nor motor symptoms occurs in PD patients, leading to both financial and mental burdens to individuals, families and society. PD is considered as a multifactorial disease, resulting from the affect of genetic susceptibility, lifestyle and environmental factors. The relationship between lifestyle factors(cigarette smoking, alcohol consumption and tea drinking), hyperuricemia and the risk of PD have ever been reported. However, further study about the relationship needs to be down. What’s more, the relationship between hypertension and PD is rarely discussed at home and abroad. In this study, we carry out a preliminary discussion, thus providing new epidemiological information on the etiology of PD.Objective To explore the association of Parkinson’s disease with hypertension, hyperuricemia, cigarette smoking, alcohol consumption and tea drinking.Methods 372 Parkinson’s disease cases and 372 controls matched on gender, age were recruited from the Second Affiliated Hospital of Soochow University from 2011.1 to 2013.1. Data on hypertension were analyzed in a case control study. Information on demographics, lifestyle exposures, hypertension and hyperuricemia was obtained through in-person interviews with structured questionnaires. Mantel-Haenszel(M-H)X2 Test was used to estimate odds ratios(ORs) and 95% confidence intervals(CI) for each factor. Multivariate logistic regression was then used to find out the independently associated factors of PD among the factors that appeared significantly associated with PD in M-H)X2 analysis. ORs and 95% CI were calculated for every factor. P<0.05 was considered statistically significant in our study.Results The study revealed significant protective effect of hypertension, hyperuricemia, cigarette smoking, alcohol consumption and tea drinking on PD. Univariate analysis(ORhypertension =0.05,95%CI:0.37-0.70;ORhyperuricemia =0.24,95%CI:0.15-0.37;ORsmoking =0.34,95%CI:0.24-0.48;ORalcohol =0.25,95%CI:0.16-0.39;ORtea =0.25,95%CI:0.18-0.35); Multivariate analysis(ORhypertension =0.61,95%CI:0.44-0.84;ORhyperuricemia =0.25,95%CI:0.16-0.38;ORsmoking =0.48,95%CI:0.30-0.77;ORalcohol =0.33,95%CI:0.19-0.55;ORtea =0.26,95%CI:0.18-0.38).Then we carried out stratified analysis for the patients of hypertension.the stage of hypertension(ORⅠ=0.85,95%CI:0.58-1.24;ORⅡ=0.40,95%CI:0.26-0.62;ORⅢ=0.20,95%CI:0.11-0.36).The course of hypertension was also performrd(OR<10years=0.56,95%CI:0.40-0.76;OR≥10years=0.35,95%CI:0.21-0.58),showing that the negative correlation was still existent and had a trend of dose-response relationship.(P<0.05).Conclusion There was an inverse association between Parkinson’s disease and hypertension, hyperuricemia, cigarette smoking, alcohol consumption, tea drinking.