The Association Of The Rs1014290 In SLC2A9 With The Development Of Parkinson’s Disease Through Uric Acid Metabolism

Objective: To describe the modulation effect of the genotypes of rs1014290 in SLC2A9 on the development of Parkinson’s disease(PD) in a cohort of PD cases of Han Chinese and the association with serum uric acid level.Methods: Between January 2011 to November 2012, 160 unrelated Han subjects with PD from Neurology Department, Second Affiliated Hospital of Sooc how University, C hina and 160 unrelated community residents as controls matched in gender and age of the same ethnic group from the same period were included in the case-control study. Uric acid was tested by Beckman-coulter(USA) automatic biochemical ana lyzer and their original kits in The Second Affiliated Hospital of Soochow University. SNP rs1014290 was assayed using a mutation-sensitive on/off switch technology.Results: Uric acid levels of PD patients were significantly lower than ones of controls. Individuals who carried TT and CT genotypes had higher uric acid levels, and those who harbored CC genotype had the lowest uric acid level in normal controls. The CC genotype and the C minor allele of the single nucleotide polymorphism(SNP) rs1014290, whic h are related to lower uric acid levels, were more statistically more frequent in the PD group than the control group.Conclusion: The present study has demonstrated genotype-phenotype association of the rs1014290 in SLC2A9 to the development of PD through uric acid metabolism in Han Chinese. It can be a risk factor for PD in Han population.