The Relationship Between Ischemic Cerebral Small Vessel Disease And Serum Bilirubin Level In Male Elderly Patients

Objective:1. To investigate the association of white matter lesions (WML) with serum bilirubin level in elderly male patients.2. To investigate the association of lacunar infarction(LI) with serum bilirubin level in male elderly patients.Methods:At last, a number of 92 cases of male WML patients and 98 cases of male LI patients were selected in this study. White matter lesions and lacunar infarction was detected on MRI. WML according to Age-Related White Matter Changes scale divided into mild(49 cases) and moderate-severe(43 cases) groups. LI patients according to lesions number divided into single(36 cases) and multiple(62 cases) groups. All patients documented Medical histories, including chronic bronchitis, chronic obstructive pulmonary disease(COPD), coronary disease, stroke, transient ischemic attack(TIA), age, the history of smoking, drinking and laboratory test. Compare the serum bilirubin level and other clinical information between the two groups. All the WML patients according to total bilirubin divided into upper tertile (14.1-21umol/L,13 cases)、middle tertile (7.1-14.0umol/L,63 cases) and lower tertile(0-7.0umol/L,16 cases), compare WML scores and other clinical information between the three groups. All the LI patients according to total bilirubin divided into upper tertile (14.1-21umol/L,14 cases)、middle tertile (7.1-14.0umol/L,66 cases) and lower tertile(0-7.0umol/L,18 cases), compare the number of lesions and other clinical information between the three groups. Data were analyzed using SPSS, version 17.0. Continuous data were presented as mean+SD. Student t test was used for between group-comparisons. Non-normal distribution data use Wilcoxon rank sum test. The chi-square test was used for nominal data. The risk factors for WML and LI were calculated using multivariate logistic regression. All tests were considered significant if p<0.05.Results:1. For the serum level of indirect reacting bilirubin, serum level of direct reacting bilirubin and serum level total bilirubin, there were no significant changes being observed between the WML mild group and WML moderate-severe group (P>0.05). For the WML scores was 6.1vs5.9vs7.1(P=0.85) according to total bilirubin tertiles, there are no significant changes being observed between the three groups(P>0.05). Multivariate logistic regression for WML shows that no risk factors after adjusted for other factors.2. For the serum level of indirect reacting bilirubin, serum level of direct reacting bilirubin and serum level total bilirubin, there were no significant changes being observed between the single and multiple groups (P>0.05). The number of lesios was3.9vs3.2vs3.2(P=0.53)according to total bilirubin tertiles, there are no significant changes being observed between the three groups(P>0.05). Multivariate logistic regression for LI shows that no risk factors after adjusted for other factors.Conclusion:1. There were no association of white matter lesions with serum bilirubin level in male elderly patients. There were no significant risk factors for WML in this study.2. There were no association of lacunar infarction with serum bilirubin level in male elderly patients. There were no significant risk factors for WML in this study.