The Association Study Between C-reactive Protein And Cerebral Small Vessel Disease

Objective:To investigate the association between C-reactive protein(CRP) and presence of cerebral small vessel disease and progression of white matter lesions.Methods:38peoples were chosen as normal control team,38peoples were chosen as cerebral small vessel disease(SVD) team, SVD team was divided into white matter lesions(WML) team and lacunar infarction(LI) team according to MRI, WML team was divided into mild、moderate and severe according to Fazekas methods. Compare CRP and other cardiovascular risk factors, use Logistic regression models to assess the association between CRP and SVD、WML、LI, use analysis of variance to assess CRP among subgroups of WML team.Results:Higher CRP levels were associated with presence of cerebral small vessel disease(OR=1.321) and white matter lesions(OR=1.295), these associations persisted after adjustment for cardiovascular risk factors. Persons with higher CRP levels tended to have more prevalent and incident lacunar infarctions, but the association didn’t have statistically significant. CRP levels among mild、moderate、severe white matter lesions had no variance.Conclusion:Higher CRP levels may be a independent risk factor for presence of cerebral small vessel disease, in particular, presence of white matter lesions. However, higher CRP levels are not involved in the progression of white matter lesions.