A Survey About Serum Vitamin D Level Of Community-dwelling Medium-elderly Men In Beijing And A Preliminary Discussion On The Relationship Of Blood Glucose,Muscle Strength,Risk Of Fall And Vitamin D

Objective To investigate vitamin D status of community-dwellingmedium-elderly men in Beijing and preliminaryly explore the effect of vitamin D on blood glucose,muscle strength and risk of fall.Methods A cross-sectional survey was designed. Medium-elderly men over 40 years old were enrolled,who participated in a routine annual health creening examination of a community from March to April in 2014.Understood general information and related lifestyle by unified questionnaire.Routine blood test,liver function,renal function, calcium, phosphorus, alkaline phosphatase, fasting blood glucose, postprandial blood glucose, uric acid,lipids and 25 (OH) D were measured by fasting blood samples. Body height,weight,blood pressure,muscle strength and risk of fall were measured by specialized persons.Results 1.The mean value of serum 25 (OH) D was (16.81±5.55) ng/ml, the lowest level was5.0 ng/ml, the highest level was 40.94 ng/ml, and the proportion of vitamin D serious deficiency group, deficiency group, insufficiency group and sufficiency group were 7.23%,70.18%,19.88%,2.71%.There were significant differences of 25 (OH) D between different age groups(P<0.05),25 (OH) D increased with the growth of age (P<0.05).The analysis of correlation relationship indicated that 25 (OH) D was significantly positive correlated with age (r=0.23,P=0.00).After adjustment for BMI,FBG,PBG, SBP, DBP,TG,TC,LDL-C and HDL-Cby partial correlation analysis, 25 (OH) D still was significantly positive correlated with age (r=0.30,P=0.00).25 (OH) D levels were different between different lifestyles,but did not reach statistics significance (P>0.05)。After adjusted intake of milk, sunshine duration, exercise frequency and working environment, there were no significant difference in the level of 25 (OH) D among groups by age.2.25 (OH) D levels were significant different between different glycometablic groups,25 (OH) D level of DM group was significant below than NGR group(13.94±3.10ng/ml VS17.01±5.59ng/ml) (P< 0.05).FBG and FPG decreased with 25 (OH) D increased. Correlation analysis showed that FBG and PBG were significant negative correlation, but did not reach statistics significance (r=-0.094,-0.112). After adjustment for age,BMI, and UA by partial correlation analysis, FBG and PBG were significant negative correlated with 25 (OH) D level(r=-0.16,-0.17, P=0.01,0.01).The result of bivariate logistic regression analysis showed the level of 25 (OH) D was not related to impaired glycometabolism.3.With the increase of age, the grip, pinch strength and muscle strength of lower limbs decreased gradually. Time and abnormal rates of timed get-up and go test (TGUT) and chair rising test(CRT) increased (P<0.05). The grip and pinch strengths in serious deficiency group were significant below than other groups. After corrected age, there were all significant difference among groups by 25 (OH) D level in concentration of serum calcium, grip, pinch strength and muscle strength of lower limbs.,and there were lowest level in the serious 25 (OH) Dseriousdeficiency group. There were independent relationship among increasing age, decreased grip and 25 (OH) D deficiency with the OR values of 1.37 and 1.33 respectively.Conclusions:1.The mean 25 (OH) D status of community-dwelling medium-elderly men in Beijing was 16.81±5.55ng/ml, proportion of 25 (OH) D deficiency and insufficiency groups were as high as 97.3%. The analysis of correlation relationship indicated that 25 (OH) D was significantly positive correlated with age,but the correlation may be influnenced by different lifestyles.2.25 (OH) D level decreased with the aggravating of abnormal glucose metabolism. After adjustment for age,BMI and UA by partial correlation analysis,FBG and FPG were significant negative correlated with 25 (OH) D level. The results of bivariate logistic regression analysis showed the levels of 25 (OH) D were not related to impaired glycometabolism.3. With age increasing, risk of fall increased and muscle strength decreased.25 (OH) D deficiency had independent correlated relationship with aging and strength of upper limb.