The Effect Of Vitamin D Supplementation On Blood Pressure And Blood Glucose In Elderly Primary Hypertensive Patients

Objective:To investigate the effect of the vitamin D (Vit D) lack and limitation of elderly hypertensive patients given vitamin D supplementation on the systolic blood pressure (SBP), diastolic blood pressure (DBP) and fasting blood glucose(FPG). Methods: A random sample of199elderly residents at Six Bay community in Urumqi city, to examine the serum levels of vitamin D, calcium and fasting plasma glucose, and to measure the height, the weight and the blood pressure. According to the levels of serum vitamin D lack and deficiency,60patients with essential hypertension were randomly selected, based on conventional therapy plus Luogaiquan (Calcitriol capsule), continuous taking three months, comparing the difference of before and after treatment about the above index. Results:The data suggested that body mass index(BMI), blood pressure and fasting plasma glucose in abnormal blood pressure group were higher than normal blood pressure group, vitamin D level was lower than the normal blood pressure group [FPG:(6.14±0.52) vs (5.80±0.53) mmol/L, BM1:(25.73±4.10) vs (23.64±4.10) kg/m2, Vit D:(14.20±8.09) vs (17.55±10.04) ng/ml,Ca:(2.26±0.10) vs (2.29±0.13) mmol/L; P<0.05]. Compared with the relative lack group and with adequate group, fasting plasma glucose of the vitamin D lack group were higher, serum calcium of that were lower [FPG:(6.05±0.54)vs (5.79±0.57) mmol/L,(6.05±0.54) vs (5.65±0.45) mmol/L, Ca:(2.26±0.11) vs (2.32±0.09) mmol/L,(2.26±0.11) vs (2.31±0.12)mmol/L; all P<0.05]. Pearson correlation analysis showed that serum vitamin D level and fasting plasma glucose levels were negatively correlated (r=-0.192,P<0.01), serum calcium was positively associated (r=0.247, P<0.01).After supplying Vitamin D, systolic blood pressure, diastolic blood pressure and fasting plasma glucose levels were lower than the original level, vitamin D and calcium were higher than the original level [SBP:(131.21±13.44) vs (141.06±12.96) mmHg, DBP:(82.59±9.52) vs (88.85±10.61) mmHg, FPG:(5.93±0.48) vs (6.13±6.23) mmol/L, Vit D:(16.32±4.65) vs (13.68±4.92) mmol/L, calcium:(2.34±0.14) vs (2.28±0.14) mmol/L; all P<0.05]. Conclusion:Elderly essential hypertensive patients have higher fasting plasma glucose than normal blood pressure people, and more susceptible to vitamin D deficiency. Vitamin D supplements can reduce blood pressure and fasting plasma glucose levels in elderly patients with essential hypertension.