Study On The Relationship Between Changes Of Coagulation And Bleeding Indexes In Patients With Sepsis And Wi Qi Ying Xue

ObjectiveThe patients with sepsis were pointing weiqiyingxue, determination of each patient’s PT, APTT, AT-Ⅲ, FIB, DDi, PLT, and then do the acute physiology and chronic health evaluation Ⅱ and DIC score. Through the data by statistic treatment, we can understand the correlation of weiqiyingxue syndrome and sepsis, coagulation function changes in severity of illness. To provide a new perspective for the evaluation of severity of sepsis and provide new thinking direction in TCM treatment of sepsis.MethodsThis was a retrospective study. The Experiment included 101 cases of sepsis patients between December 2013 and November 2014 in the Intensive Care Unit, each patient was record the information of four diagnostic methods. BY weiqiyingxue dialectical method, all patients were divided into four groups, record each patient’s APTT, AT-Ⅲ, PT FIB, DDi, PLT, and DIC integral ISTH within 24 hours after admission and according to APACHE Ⅱ. Data were processed using SPSS 19 statistical software. The detection of numerical detecting whether is normal distribution, normal distribution or approximate normal distribution numerical measurement data with x+s, the measurement data of non normal distribution with median and range (minimum, maximum), compared between the two groups using t test, compared among groups by single factor ONE WAY ANOVA test, group compared with the Bonferroni test. Grade data using non parametric test, count data using chi square test. PT, APTT, AT-Ⅲ, FIB, DDI, PLT, DIC integral and weiqiyingxue dialectical correlation analysis using Spearman rank correlation analysis, and the APACHE Ⅱ score using Pearson or Spearman rank correlation analysis, Spearman rank correlation analysis of APACHE score of Ⅱ and TCM syndrome type with bilateral. the difference statistically significant was P<0.05, P<0.01 was significant differences.Results1. Comparison of sepsis in patients with APACHE II score:Xuefen syndrome group, Yingfen syndrome group score higher than Qifen syndrome group (P< 0.05), Xuef en syndrome group was higher than that of the Yingfen syndrome group (P> 0.05), but the difference was not statistically significant. Application of Spearman correlation analysis indicated that, There is a positive correlation between the weiqiyingxue and APACHE II scores (P< 0.05).2. Comparison of sepsis in patients with Coagulation and bleeding indexes :Xuef en syndrome group, Yingfen syndrome groups’PT, two D-dimer than Qifen syndrome group (P< 0.05), Xuef en syndrome group was higher than that of the Yingfen syndrome group (P> 0.05), but the difference was not statistically significant. Application of Spearman correlation analysis showed that:There is a positive correlation between weiqiyingxue syndrome and PT, the two D-dimer (P< 0.05).Xuefen syndrome group platelet count below the Yingfen syndrome group, Qifen syndrome group (P< 0.05), Yingfen syndrome group was higher than that of Xuefen syndrome group (P> 0.05), but the difference was not statistically significant. Application of Spearman correlation analysis showed that:there is a negative correlation between the platelet count and weiqiyingxue syndrome (P< 0.05).3. Comparison of APACHE Ⅱ score and PT, PLT count, D-two dimer correlation:APACHE Ⅱ score and PT, D-two dimer expression level was a positive correlation (P< 0.05), and there is a negative correlation between the APACHE II score and PLT count (P< 0.05).4. Comparison of various types of patients 28 day mortality:The Qifen Group’s mortality was 9.7%. The Qifen Group’s mortality was 53.1%. The xuefen Group’s mortality 57.9%. There is a significant difference in comparison Qifen with Xuefen P<0.01; Yingfen and Xuefen groups have no statistical significance.5. Comparison of survival group and death group:death group PT, two D-dimer, APACHE II score higher than the survival group (P<0.05), PLT count below the survival group.Conclusion1. Patients with sepsis severity of illness and the theory of weiqiyingxue process is basically the same. In the clinical work, the theory of Weiqiyingxue syndrome can be a certain degree of the severity and prognosis of the disease in specis.2. The coagulation system is involved in the pathogenesis of sepsis. Septic illness is more serious, the two D- dimer expression level is high, prolonged PT, PLT count is lower, the mortality is also higher. Coagulation index can reflect the sepsis severity of illness, and it can be used as a clinical index of severity and prognosis in critically ill judged.3. There is a positive correlation between Weiqiyingxue syndrome and APACHE II score, two D- dimer, PT.There is a negative relationship between Weiqiyingxue syndrome and PLT count. APACHE Ⅱ score, two D- dimer, PT changed little, the counts of PLT high, low mortality in the qifen patients; Yingfen and Xuefen patients with high APACHE Ⅱ scores, D- two dimer, PT, low PLT counts, high mortality. Combination of TCM and Coagulation and bleeding indexes in the Clinical, will be helpful to judge prognosis in patients with spesis.