Diagnosis Of Hemostatic Abnormality In Sepsis And Study On The Strategy To Interfere With The Regulatory Dysfunction Of Coagulation System

Background: Sepsis with its ensued MODS, is a major cause of death in ICU. Its mechanism is believed to be the systemic inflammatory response caused by the host immune system to invading microorganism. As an essential component of the innate immunity, coagulation system plays an active role in the pathogenesis of sepsis. With the growing knowledge in this area, there is a great amount of interest among clinician in trying to supplement the natural anticoagulants, such as APC, AT-III etc. as part of sepsis treatment. However, it turns out that the efficacy of anticoagulant supplementation partly depends on the extent of the dysfunction of coagulation system, and the consequences of the abnormal regulatory mechanisms could not be totally corrected by simple supplementation.Object: To characterize the abnormalities of coagulation system in severe septic patients. To explore screening tests for the coagulation abnormalities in severe sepsis. To compare the relative importance of each regulatory mechanism on the outcome of the patients. To test the effects of potential protective factors on regulatory mechanism of endothelial cells in vitro.Method: A prospective case-control study was carried out in PUMCH ICU, in which sixty-three patients with diagnosis of sepsis, as well as 34 control patients were studied. Serial blood samples were obtained on days 1,3,5 for the septic patients after the diagnosis was made, and were...