Effectiveness Of High Dose Atorvastatin On Preventing Contrast-induced Nephropathy After Cerebral Vascular Interventional Therapy

Objective To investigate the effect of high dose atorvastatin on the prevention of contrast -induced nephropathy (CIN)and its mechanism of action.Methods We chosed 95 cases of patients whom were diagnosed with cerebral vascular diseases and scheduled for diagnostic and therapeutic cerebral vascular intervention in our hospital from July 2014 to December 2014,and they were divided into the observation group(n=49) and the control group(n=46) randomly.3 days before surgery and after surgery, the observation group receive atorvastatin 20mg/d,the observe group receive atorvastatin 80mg once on the night before surgery,and receive atorvastatin 20mg/d after surgery. The SCR(serum creatinine), CCR(endogenous creatinine clearance),BUN(blood urea nitrogen),β2-MG(P2-micro globulin), GYS-C(cystatin c), hs-CRP (high sensitivity C reactive protein) of two groups were observed in the ldours before surgery,24 and 72 hours after surgery. The blood lipid, liver function of two groups were observed in the 1dours before surgery and 72 hours after surgery.Results Levels of SCR, CCR, BUN, β2-MG, GYS-C, hs-CRP showed no significant differences between these two groups before surgery.SCR, β2-MG, GYS-C, hs-CRP levels were increased and CCR levels were decreased in the control group after surgery (P<0.05). GYS-C levels were increased in the observation group after surgery (P<0.05). Levels of index showed no significant differences between these two groups after surgery. Compare the liver function and blood lipid levels between and within these two groups before and after surgery, there had no statistical significance.Conclusions High-dose atorvastatin may be effective in protecting cerebral vascular diseases patients undergoing Cerebral vascular interventional therapy from CIN. The underlying mechanism may relate with the significant inhibition on the inflammatory response.