Efficacy And Influencing Facters Analysis Of Neoadjuvant Chemotherapy For Breast Cancer

Objective:To investigate the efficacy and influencing factors of neoadjuvant chemotherapy in breast cancer.Methods:167 cases operable stage Ⅱ,Ⅲ breast cancer patients were performed with anthracycline、paclitaxel or xeloda class-based neoadjuvant chemotherapy, the efficacy was evaluated by MRI imaging methods every two chemotherapy cycles.Factors affecting the effect of chemotherapy was determinated by univariate analysis and multivariate Logistic regression analysis.Results:in the 167 cases breast cancer patients,the complete remission (CR) 24 cases(14.4%),of which pathological complete response (pCR) 20 cases (12%),partial remission (PR) 90 cases(53.9%),stable disease(SD) 43 cases(25.7%), progressive disease (PD) 10 cases(6%), The overall effective rate was 68.3%. Univariate analysis showed that:Influence of the facters,such as tumor size、calcification、ER、PR、chemotherapy cycles and chemotherapy regimens,on neoadjuvant chemotherapy for breast cancer was statistically significant (P<0.05).In patients whose tumor diameter≤3cm, mammography no calcification, ER or PR negative, the number of chemotherapy cycles≥4,Anthracycline plus Xeloda regimen, the efficacy of neoadjuvant chemotherapy is better, CR rate is higher. Multivariate analysis showed that: tumor size was an independent predictive factor for CR rate to neoadjuvant chemotherapy,With the increase in tumor size,CR rate gradually decreased.Conclusion:1、The neoaduvant chemotherapy for breast cancer have a good recent effect, can obviously reduce tumor lesions, and achieve the purpose of reducing the stage.2、Tumor size、calcification、PR、ER、chemotherapy cycle and chemotherapy regimen are the influencing factors of neoadjuvant chemotherapy for breast cancer, and tumor size is the independent influencing factor.