Clinical Study Of Using Li Shimao’s Diaphoresis Method To Treat Coagulated Cold Syndrome Type Of Knee Osteoarthritis

Objective: Trough this paper we will observe the clinical efficacy that master of Chinese medicine Li Shimao applys sweating method on cold coagulation syndrome types of knee osteoarthritis. Exploe theory origin and the academic innovation of master Li Shimao’s diaphoresis method. Provide clinical research support to enrich and develop therapeutic principle of the master of traditional Chinese medicine group characteristics. Inherit and develop his clinical experience on sweating method of curing cold coagulation. Improve knee osteoarthritis treatment effect. Methods: To select the 120 patients in strict accordance with the diagnostic criteria for knee osteoarthritis and inclusion and exclusion criteria and divide them into three groups: Western medicine control group, Chinese medicine control group, the test group according to treatment sequence making random card 1:1 n = 40, for Western medicine control group male 9, female 31, age 40 to 70 years, an average of 59.6 years, duration of 1month to 20 years; Chinese medicine control group, 12 men, women 28, age 40 to 70 years old, with an average of 58.4 years old, duration of 1month to 20 years; test group, male 9, female 31, age 40 to 70 years, with an average of 57.2 years of age, duration of 1month to 20 years. Western medicine control group: give Diclofenac Sodium Sustained Release Tablets 75 mg oral, once a day, last 3 days. The Chinese medicine control group: given the aconite decoction modification. Prescription: "Aconite Decoction" comes from "Jingui Yaolue Synopsis of Golden Chamber".Contains ephedra, aconite, peony, licorice,astragalus membranaceus, honey; various herbs can expel the wind cold dampness with slight sweating, remove the evil and dredge meridians, not hurt healthy qi, is the representative formule to treat pain arthromyodynia, has the functions of dispelling the cold evil and dredging collaterals. Usage: a agent, twice in morning and evening. Test group: given cold convulsion decoction modification. Composition: Contains cinnamon cassia twig, gypsum, ginger, date, ephedra, asarum, acomite, centipede. This decotion can sweat and dispelling the cold evil. Scolopendra subsinipes and scorpions are antispasm powder, which can dredge collaterals, relieve urgency, pain, and muscle spasm. Usage:1 Take 200 ml at 9 point after breakfast; if do not sweat, after3 hours take 200 ml again; if still do not sweat,, take second dose, every 3 hours take one time, until healthy sweat appears. Otherwise, the next day as before take, not up to standard third day continue to take two doses. If three days take six doses, healthy sweat does not appear and convulsion pulse does not stop that do not take again and observe the index. 2 According to the third method aided sweating taking drugs: after taking the decotion drink hot gruel, cover clothes, continuous take. 3 The best sweating standards: is healthy sweating method: " healthy sweat appear, convulsion pulse stop". That is slight sweating, all over the body, last 2-5 hours and self convergence. Vein convulsion check: namely pulse string restraint also appellation "convulsion vein". We put the heavy string constrained pulse named convulsion pulse. Convulsion pulse stop is pulse tends to be moderate after treatment by sweating method. 4 In accordance with the principles of "view its pulse and syndrome, know where will invade, and treat it as is syndrome " to treat the residual symptoms that after sweating. Concomitant treatment: Health Education: 1 Reduce and avoid the knees bear weight.2 Strengthen the knee protection: wear knee pads, adhere to the use a cane and so on; 3 Strengthen functional exercise of knee jiont: tell the patient to pedal a empty bicycle and exercise extension apparatus of knee jiont. All groups were treated for 3 days, western medicine control group, take drug once daily, Chinese medicine control group take a dose daily, test group take one or two doses every day according to the condition, the course is 7days for each group. After a course of treatment, keeping scores for the symptom of its therapeutic effect. Select walking pain or discomfort, morning stiffness, joint tenderness, exacerbated by exposure to cold, adverse joint flexion and extension, joint swelling, maximum walking distance, pulse, adverse reactions as evaluation indicators to compare the three group for the total efficacy,single symptoms, signs and analyze the results to get the conclusion. Results: 1 After the treatment, three groups of patients did not show significant changes in blood count, ESR, liver and kidney function. Patients with mild cardio-cerebrovascular disease do not appear obvious discomfort. 2 Efficacy comparison: at the end of treatment, for the test group of 40 patients, 17 cases were cured, 16 cases markedly effective, 4 case effective, and 3 case not effective, the total effective rate was 92.5%; for the Chinese medicine control group of 40 patients 10 cases were cured, 14 cases were markedly effective,10 case effective, and 6 cases not effective, the total effective rate was 85.0%; for the western medicine control group of 40 patients,2 cases were cured, 13 cases markedly effective,16 case effective and 9 cases not effective, the total effective rate was 75.5%. The total efficiency rate of the three groups are statistically significant difference(P<0.01). Test group is superior to the Chinese medicine control group and the western medicine control group. 3 Treatment efficacy of single symptoms and signs comparison: the efficacy of the symptoms of morning stiffness, joint tenderness, exacerbated by exposure to cold, knee joint stiffness, tibia knee limp, maximum walking distance, tread on a flight of stairs, walk down a flight of stairs have a significant difference(P<0.05); walking pain or discomfort, joint pain at rest, adverse joint flexion and extension, from sitting to standing, take the rough road symptoms are similar efficacy, the difference was not statistically significant(P>0.05); for joint swelling, fatigue, three groups were not improved after the treatment. Conclusion: 1 Diaphoresis can effectively treat coagulated cold syndrome type of knee osteoarthritis and improve the clinical symptoms and signs and it is safe, less adverse reactions, effective,reliable and worthy of clinical promotion. 2 Li Shimao innovatively applys diaphoresis to treat interior syndrome, deficiency-excess mixing syndrome, Yang deficiency and coagulated cold syndrome, does not rigidly adhere to the exterior syndrome,enrichs theoretical research of diaphoresis, expands the scope of application of diaphoresis, obtains satisfactory curative effect in clinic.