Correlation Study Of Insulin Resistance And Chronic Obstructive Pulmonary Disease

Objective To study the correlation of insulin resistance (IR) and chronic obstructive pulmonary disease (COPD) patience’s age, sex, smoking and pulmonary function, etc. To explore the incidence of IR with COPD patience. We can carry on the better comprehensive treatment to the patients with COPD.Methods Amount of 98 patients (50 males and 48 females) with COPD were selected as experimental group, to choose another 31 healthy person (15 males and 16 females) from our department outpatient service as the healthy control group. The levels of serum FBG and FINS and age, height, weight and smoking index, lung function were measured in all subjects. The homeostasis model assessment of insulin resistance(HOMA-IR) was used as a parameter to evaluate the degree of insulin resistance. And calculate the subjects body mass index (BMI).To build up the data base and manages all the data with the software Excel. SPSS 19.0 statistical software were used to analysis all research data of different groups; Chi-square tests were used to check for significant differences of age and incidence. The difference of the measurement data such as age, FBG、HOMA-IR、FEV1/FVC were compared with the paired t test. Multiple factors regression analysis was used to analysis gender, age, smoking influence on IR. The correlation between IR and age, pulmonary function and smoking was analyzed.Result 1.The HOMA-IR of the acute aggravating period group and stable stage group is higher than the control group, and the HOMA-IR of the acute aggravating period group is higher than the stable group’s, the difference was statistically significant.(P<0.01) 2.The influence of age on the IR:positive correlations were found between age and IR(P<0.01).3.The influence of different gender in FBG,FINS and IR index:COPD stabilization, AECOPD group and healthy controls of the above-mentioned no statistically significant difference were observed in the index. (P>0.05) 4.The influence of smoking:Mild-to-moderate smokers’ FEV1/FVC, FEVlpred% declined obviously than less smokers’; however, FBG, FINS and IR index rise significantly.(P< 0.05)Heavy smokers’ FEV1/FVC, FEVlpred% declined obviously than Mild-to-moderate smokers’; however, FBG, FINS and IR index rise significantly.(P< 0.05) 5.To study the correlation between lung function(FEVl/FVC> FEVl%pred) and insulin resistant index:lung function have little effects on the insulin resistant index in the COPD stabilization and the control group(P>0.05)。 Lung function have negative effects on the insulin resistant index in the AECOPD (r=-0.642、r=-0.715, P<0.01)。Conclusion 1.There is higher incidence of IR in patients with COPD, and the emergence of IR related to disease progression. Patients with AECOPD prevalence rate of IR is higher than stable patience.2.Age and smoking are important risk factors of IR in COPD.As age or smoking index increases, the prevalence of insulin resistance is raised.3.Lung function have negative effects on the insulin resistant index in the patience with COPD.IR has relationship with the risk factor lead to airway resistance.