Updated Studies In Clinical Application Of Heart Fatty Acid Binding Protein In Pediatric Diseases

Heart fatty acid binding protein (H-FABP) is a low molecular weight protein with highly tissue specific distribution. It is one promising biomarker for evaluation of myocardial injury. H-FABP is mainly involved in cell energy metabolism system, and it is thought to provide energy for organism. H-FABP can quickly move through the damaged myocardium cell membrane to the blood. After myocardial injury, H-FABP in the blood starts to increase at about the first 1-3 hours, reaches the peak at 8 hours, and gets back to normal at 24 hours. H-FABP can be filtered through glomerlus and excreted from the body mainly by urine. H-FABP is also present in brain, skeletal muscle,lung,kidney,adrenal gland and breast tissue at low levels.Studies showed that H-FABP may be a very good myocardial injury marker with better sensitivity, specificity than the traditional markers, such as CK-MB, CTnI. H-FABP is widely used as a marker for early diagnosis, risk stratification and prognosis assessment in myocardialinfarction, pulmonary embolism. The levels of serum H-FABP were increased in brain cancer, breast cancer, neurological disorders, such as Stroke, Dementia and Parkinson Disease, and Renal Transplantation, but the correlation between H-FABP and these diseases remains elusive. Many studies have focused on the role of H-FABP in adult diseases, this review presents an overview of some recent studies on the role of H-FABP in pediatric diseases.