| Objective:This study aimed at exploring the plasma homocysteine levels of patients with H-type hypertension, the effects of changes in the indicators on plasma HCY and ambulatory blood pressure before and after moderate aerobic exercise. Methods:66 adults were selected as the subjects by questionnaire survey and health screening before exercises, including 44 hypertension patients and 22 adults with normal blood pressure. They were divided into experimental group and control group. The experimental group was given exercise intervention for 12 weeks. Data was shown as mean±SD.All calculations and statistics were performed with SPSS13.0.The Kolomogorov-Simirnov single sample test was used testing if the data’s distribution is normal.The changes of all the indices were analyzed with statistical software, including paired-samples T test, independent-samples T test, Mann-Whitney U nonparametric rank test and Wilcoxon rank test.Results:(1) The average of the Plasma HCY in patients with H-type hypertension was higher than that of adults with normal blood pressure (14.81±5.44μmol/L vs 10.66 ±2.77μmol/L,P=0.001).The proportion of hypertension patients with the high level of HCY was 88.64%. (2) There was no significant difference between the hypertension patients and adults with normal blood pressure under the rest state, but for all indicators of 24-hour ambulatory blood pressure, the hypertension patients was higher than that of adults with normal blood pressure(P<0.01). (3) After 12 weeks, the average of Plasma HCY of the experimental group showed significant decline (from 17.94±3.69μmol/L to 12.87±2.79μmol/L, P<0.01), but that of the control group shown non-significant changes (from 16.54±3.52μmol/Lto 14.81±2.23μmol/L, P=0.117).(4) After 12 weeks, the 24-hour ambulatory blood pressure variability of the experimental group shown significant decline (SBP:from 12.20±1.75% to 8.97 ±1.23%,P<0.001;DBP:from 15.91±3.84% to 11.37±1.45%,P=0.010),but that of the control group shown non-significant changes (SBP:from 12.43±1.03% to 12.44 ±1.65%,P=0.985;DBP:from 15.35±2.74% to 17.31±3.40%,P=0.089). (5) After 12 weeks, the 24-hour ambulatory blood pressure load of the experimental group shown significant decline(SBP:from 32.16±13.57% to 17.65± 11.44%,P=0.001;DBP:from 9.96±6.89% to1.59±1.90%,P=0.004),but that of the control group shown non-significant changes (SBP:from 23.95±18.07% to 26.36± 11.87%,P=0.411;DBP:from 12.40±7.34% to 13.94±6.97%,P=0.578).(6)After 12 weeks, morning blood pressure of the experimental group shown significant decline (SBP:from 29.55±9.38mmHg to 14.48±5.88mmHg,P=0.001;DBP:from 19.67± 11.47mmHg to 11.39±6.01 mmHg,P=0.007), but that of the control group showed no significant changes(SBP:from 30.58±12.05mmHg to 27.21± 10.35mmHg,P=0.235;DBP:from 26.83±11.08mmHg to 26.04± 10.21mmHg,P=0.692)Conclusions:(1) The HCY level of hypertension patients is higher than normal, and the proportion of elevated homocysteine level is as high as 88.64%. (2) 12 weeks’moderate intensity aerobic exercises could effectively reduce plasma HCY for hypertension patients.(3) 12 weeks’ moderate intensity aerobic exercises could effectively lower the blood pression between 6am-8am and morning blood pression, which was better than single drug therapy. (4)12 weeks" moderate intensity aerobic exercises could effectively lower blood pression variability and the frequency of abnormal blood pressure, which was better than single drug therapy. |
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