| Objective:Ankylosing spondylitis is no solution to modern medicine.Traditional Chinese medicine treatment of ankylosing spondylitis to relieve symptoms, delay the disease development has a good curative effect, also has the very big development space. So the use of TCM inheritance support system to experienced doctor of traditional Chinese medicine professor Hu Yinqi prescriptions for data mining for the treatment of ankylosing spondylitis,and analysis of the drug treatment of ankylosing spondylitis experience, analysis of his characteristics, summarizing its drug laws,and finally dig new prescription, thus enriching and optimization based on the experience of the medical diagnosis and treatment schemes of ankylosing spondylitis.For the TCM treatment of ankylosing ridge phlogistic column provides another kind of statistical classification and calculation of the objective, system analysis method, to study medical experience provides a new way, make doctors experience rise further provide the basis for clinical evidence.Methods:Collected from July 2007 to January 2015 Hu Yinqi professor in Wangjing hospital and the Guang’anmen hospital outpatient prescriptions treating patients diagnosed with ankylosing spondylitis, the total 261 prescriptions.Using China project team to develop new drugs of traditional Chinese medicine academy of sciences institute of traditional Chinese medicine (TCM) design of the TCM inheritance support system software to analyze medical record of the prescription.For entry of traditional Chinese medicine prescription data mining and analysis, summarize professor Hu’s using laws of drugs and characteristics of treatment of ankylosing spondylitis, finally extract new prescriptions,and sum up the experiences of professor Hu Yinqi treatment of ankylosing spondylitis medication.Results:Through the analysis of 261 prescriptions, the results showed that the drugs used a total of 234, a total of 4357 times, on average every party 16 times. Drags be visible by the analysis of frequency from high to low in turn to liver, kidney, spleen, stomach, lung, bladder, heart, intestine, bile and small intestine, classics;Used more than 60 tastes’s drugs are:caulis spatholobi, radix puerariae, eucommia bark, centipede, radix cyathulae, radix clematidis, radix paconiac alba, radix dipsaci, yuan hu, common clubmoss herb, radix linderae, hot dogs, turtle shell, black tip snake ridge, prepared rhizome of rehmannia, cortex phellodendri, Bi Xie, glabrous greenbrier rhizome, notopterygium, notoginseng powder, sandalwood, batryticated silkworm, accounting for 55.34% of the total taste time.After medical statistical four gas analysis shows, with the most warm peaceful drug application, and then according to the cool, cold, hot drugs reduced;the drug mixed statistical analysis can be seen, the bitter herbs, spicy herbs and the sweet herbs, most then press salty, sour, bitter, mild decline in turn.Through the analysis of 261 prescriptions, found that the frequency in accordance with the drug combination each other from high to low order, a total of 155 data. Contains 21 kinds of traditional Chinese medicine, The top five combinations are caulis spatholobi, radix puerariae, respectively,eucommia bark, caulis spatholobi, suberectstem, centipede, puerarin, centipede, caulis spatholobi, radix clematidis. System independently choose the appropriate support number (70) and confidence (0.9), and through the analysis of the rules of association rules and then click the button, can export 34 medication rules. Using the inheritance of traditional Chinese medicine auxiliary platform combination entropy hierarchical clustering method to extract a new prescription to treat ankylosing spondylitis article 13.Conclusion:Through the use of TCM inheritance support system on experienced doctor of traditional Chinese medicine professor Hu Yinqi of ankylosing spondylitis medication rule data mining research, the commonly used drugs, commonly used to finishing, the correlation between the drug and remove the previous traditional collection with teacher study basis and statistical study of subjectivity, in a new way of associated gained new knowledge and information, the experience of treatment of ankylosing spondylitis and inheriting the Hu Yinji professor provides a new way of analysis and focus.This study,also has its limitations,such as the lack of sample size,or data mining method using association rules and clustering research common medicine for, sets of rules, such as combination of core and new prescription still need further clinical treatment effect, to be on the premise of combination of traditional Chinese medicine theory and practice of comprehensive analysis and evaluation.After comparing the results of this study and the rules of traditional Chinese medicine treatment of ankylosing spondylitis can be thought of inheritance of traditional Chinese medicine auxiliary system for in-depth analysis, digging experienced doctor of traditional Chinese medicine provides a good platform, is worth further promotion and application. |