To Investigate The Attenuation And Synergistic Effect Of Hydrogen Rich Water In Malignant Tumor Patients During Chemotherapy

Objective1.The main purpose of this paper is to study the hydrogen rich water(Hydrogen Water) attenuated synergies in malignant tumor patients during chemotherapy.2.Study of hydrogen rich water in cancer patients with chemotherapy effect. To explore the application of hydrogen rich water after chemotherapy patients of bone marrow suppression, myocardial damage, heart function, liver function, renal function, gastrointestinal reaction, and the effects of related data of physical fitness.Method1.Cases: 2013 November to 2014 February in the choice of oncology in Shandong province Taishan hospital diagnosis for malignant tumor patients with a total of 80 cases were analyzed retrospectively, including 48 cases of male, 32 cases female. The maximum age is 76 years old, the youngest 35 years old, the average age is 56.5 years old. In 40 patients with lung cancer, 20 cases of gastric cancer, 10 cases of colorectal cancer, 10 cases of breast cancer. All the patients enrolled were cytologically confirmed malignant tumor pathology. Were randomly divided into two groups. The treatment group of 40 cases, 40 cases in the control group, treated with conventional chemotherapy.2.Experimental methods: two groups were treated with chemotherapy, administered according to the conventional scheme, non small cell lung cancer(NSCLC) study(GEM) + cisplatin(DDP) scheme. Gastric cancer Asha Leigh Per(L-OHP) + S-1(S-1) scheme. Colorectal cancer(L-OHP) + GIO Asha Leigh Per(S-1). Breast cancer docetaxel(TXT) + cisplatin(DDP).Treatment group: all patients in the treatment group 5 days before chemotherapy, start drinking hydrogen water until 10 days after chemotherapy. Control group: all of the 5 day control group patients before chemotherapy was given oral Leucogen 20mg/ time, three times a day, vitamin B6 10mg/ time, three times a day, Inosine Tablets 200mg/ time, three times a day, 10 days after the end of chemotherapy. All patients received chemotherapy cycle were four cycle, 21 days for a cycle. All of the patients before treatment, after the end of chemotherapy drug withdrawal and chemotherapy are four cycles and stop of hydrogen rich water, blood routine test, ECG, cardiac function measurement, for a 1 time and physical status score function of liver and kidney. Evaluation of curative effect of patients in two groups according to WHO anticancer drug acute and subacute toxicity grading standards. Two groups of 1 evaluation indexes of bone marrow inhibition(I, II, III, IV); 2 gastrointestinal reaction; 3 hepatic, renal function; 4 functional status score(KPS score); 5 myocardial injury and heart function; 6 treatment completion rate. Through the WHO anticancer drugs acute and subacute toxicity grading criteria. Comparison of treatment group and control group on adverse reaction of chemotherapy effect. Observation of chemotherapy before and after application of hydrogen rich water(Hydrogen Water) on attenuated synergistic malignant tumor patients after chemotherapy.Result1.Application of hydrogen rich water(Hydrogen Water) is the malignant tumor patient attenuated synergies efficiently, and significantly better than the control group.2.Through comparison study can be found in hydrogen water protective effect on bone marrow suppression, both numerical and control group red blood cells and platelets were significantly different(P< 0.05), there was statistical significance.3.Through the comparative study of 3 can be found in hydrogen water has a protective e effect on the liver and kidney function, mainly manifests in the treatment group patient transaminase and blood urea nitrogen creatinine level were better than the control group, there was significant difference compared with the control group(P< 0.05), there was statistical significance.4.Through the control study to show that hydrogen water has a protective effect on the heart, the treatment group ECG ischemic index and cardiac ultrasound of the heart function index compared with the control group had significant difference(P< 0.05), there was statistical significance.5.Based on WHO anticancer drugs acute and subacute toxicity grading standards through comparative study can be found in hydrogen water has a protective effect on the gastrointestinal tract, there is significant difference compared with the control group(P< 0.05), there was statistical significance.6.According to the functional status score(KPS score) standard, through comparative study can be found in hydrogen water protective effect on physical condition, there was significant difference compared with the control group(P< 0.05), there was statistical significance. ConclusionThrough before and after chemotherapy and chemotherapy in the process of daily drinking water with hydrogen and the taking of Leucogen 20 mg TID, vitamin B6, 10 mg TID, 200 mg TID Inosine Tablets compared to patients, can be drawn: hydrogen rich water(Hydrogen Water) in the chemotherapy of patients with malignant tumor patients can play a synergistic effect attenuated, to protect protect the bone marrow, gastrointestinal function, protecting liver and kidney function, heart function, myocardial protection, reduction of energy caused by improved after chemotherapy.