Study Of Effects And Traditional Chinese Medicine Approach To Observe Stagnation Of QI And Blood Stasis For The Treatment Of Chronic Pelvic Inflammatory Disease

1 Objective: To explore the effect of Chinese multi way to drug treatment of qi stagnation and blood stasis type chronic pelvic inflammation, chronic pelvic inflammatory disease, CPID) clinical efficacy and observe anxiety and depression status of CPID related mechanisms.2 Methods2.1 Theoretical research: through the study of a large number of documents, analysis of CPID and traditional Chinese medicine "qi stagnation and blood stasis", summed up the CPID related TCM etiology and pathogenesis of TCM theory, illustrates the CPID governance based on the theory from "blood stasis".2.2 Clinical study: 62 cases of CPID patients according to treatment time 1: 1 random grouping principle, divided into the treatment group(by ongluo Penqiangyan side oral+ enema + ginger moxibustion) and control group(by ongluo Penqiangyan side oral +across the Jiang Jiu) with 31 cases in each. Using the Hamilton Anxiety Scale(HAMA)and self rating Depression Scale(SDS) for comprehensive evaluation, using the Japanese half / full automatic biochemical analyzer Toshiba series detection of complement C3, using automatic special protein analyzer generation Shanghai de Ling company, determination of hs-CRP;Using double antibody sandwich ABC-ELISA method for detection of FDP, blood rheology index by Westergren method determination; and a detailed analysis of CPID in patients with general demographic data, the correlation integral signs and symptoms, quality of life, anxiety and depression value etc.;Use SPSS17.0 statistical software to analysis processing, in order to compare the efficacy between the two groups before and after treatment of HAMA and SDS and comprehensive score values, serum high sensitivity C- reactive protein(hs-CRP), blood rheology, D-D, change situation and related indexes of complement C3 content in serum and FDP.3 Results3.1 The results of theoretical study3.1.1 "Stasis" for patients with CPID in the occurrence and development of disease causesThe general situation of qi stagnation and blood stasis type machine for CPID patients "blood stasis, stagnation in the uterus", the existence of "wet, blood stasis, deficiency" of the three is the typical pathological state, regardless of the type of pathogen cure, in the final analysis are mainly "stasis".The ferrite, loss, external evil headed to, nor festival diet, spleen, in the course of time, the viscosity of wet phlegm stasis Erzhi;second, the long illness easy impairing Qi, Qi deficiency blood not handsome, cause the blood line of weakness, deficiency of Qi and blood stasis;Third, liver disorders Chang, Shuxie dereliction of duty, qi stagnation and blood stasis; fourth, the seven emotions disturb stimulation, fight blood, loss and Chong Ren and Du belt, stasis of uterus and the incidence of;3.1.2 Qi stagnation and blood stasis type CPID patients have different degree of anxiety depression statesPatients with qi stagnation and blood stasis type CPID exist different degree of anxiety and depression phenomenon, because of illness, patients have more irritability,depression, depression, negative work, that the attention is not centralized, often feel lack of meaning of life, loss of confidence performance. Moreover, with the progression of the disease, clinical symptoms gradually.3.1.3 The presence of CPID in patients with qi stagnation and blood stasis type immune function disorderQi stagnation and blood stasis type CPID patients because of the disorder of the immune function, and the existence of pelvic blood circulation dysfunction, the body to resist outside in evil, ability decreased significantly. Moreover, to promote thedevelopment of the immune function of the patients with disease duration, intensity,consistency.3.2 Study on the changes of scores and demographic data correlation of qi stagnation and blood stasis type CPID in patients with HAMA and SDS scale3.2.1 Analysis from the demographic data, with increasing age patients, are positively related to anxiety and depression. Second, spatial difference, the influence of different level exists for anxiety and depression, anxiety and depression of patients living in city is higher than that of rural area. Third, the degree is low, the more severe the patients with anxiety and depression. Fourth, the longer the duration, the more times of onset, the patient’s physical and mental suffering is more big, the higher the scores of anxiety and depression.3.2.2 Qi stagnation and blood stasis type CPID patients severity grading standard.In accordance with mild, moderate, severe is divided into three levels, the level of serum hs-CRP, comparing patients obtained: the levels of serum hs-CRP in patients with severe group was significantly higher than that of mild group and moderate group,the serum level of hs-CRP was significantly higher than that of mild group, moderate group.3.2.3 Integral, TCM syndrome type of qi stagnation and blood stasis in patients with local signs of CPID integral correlationCPID patients with mild, moderate, and severe three local symptom integral, syndrome classification quantization integral positive correlation.3.2.4 Qi stagnation and blood stasis type CPID patients compared with normal control group and related experimental indexes of blood rheological changes in specific performance, the CPID patient blood rheology detection index value increased,especially in the whole blood viscosity, plasma viscosity, hematocrit index abnormal.3.2.5 Comparison of the changes of light in weight of three groups of blood rheology and the relevant experimental index of CPID patients of qi stagnation and blood stasis type, light in weight between the three groups showed severe group blood rheology numerical was significantly higher than that of mild group and moderate group,moderate group blood rheology numerical than in mild group. Moreover, patients with depression, anxiety index score and blood rheology were positively correlated,negatively correlated and complement C3, D-D, FDP was positively associated with.3.3 The results of clinical research3.3.1 To compare the effect of the two groups before and after treatment(1) Compared with previous treatment: 1. Chinese medicine multiple routes of administration mode can significantly reduce the local symptoms of CPID patients, the clinical syndrome integral quantitative grading standard integral; 2. Traditional Chinese medicine multiple routes of administration mode can effectively improve the HAMA and SDS in patients with CPID scale scores before and after treatment, the evaluation and comparison, anxiety and depression status improved significantly, the evaluation score decreased; 3.the traditional Chinese medicine. Expression of multiple routes of drug administration mode can significantly inhibit the inflammatory cells,reduce the level of hs-CRP, which makes the complement C3 numerical tended to be normal, effectively reduce blood viscosity, improve pelvic blood flow status of the patients, improve blood rheology index;(2) Compared with previous treatment: 1. Control group can effectively reduce the local symptoms of CPID patients, the clinical syndrome integral quantitative grading standard integral; 2. The control group can improve the HAMA and SDS in patients with CPID scale scores, compared and evaluated by anxiety and depression status before and after the treatment, significant improvement, evaluation score decreased;3.the control group can. Expression was significantly inhibit the inflammatory cells,reduce the level of hs-CRP, which makes the complement C3 numerical tended to benormal, effectively reduce blood viscosity, improve pelvic blood flow status of the patients, improve blood rheology index.3.3.2 The control group and the research group contrastCompared with the control group after treatment:1. Study group was better than in lower local signs of patients with CPID score, clinical syndromes quantitative grading standard integral control group;2. The research group in the improvement of CPID patients before and after treatment of HAMA and SDS scale scores than the control group;3.The inhibition of expression. In the study group of inflammatory cells, reduce the level of hs-CRP, which makes the complement C3 numerical tended to be normal,effectively reduce blood viscosity, improve pelvic blood flow status of the patients,improve blood rheology index superior to control group.3.3.3 Adverse reaction monitoring tips: study group and control group before and after treatment were no serious adverse reaction phenomenon.4 Conclusion4.1 In the type of qi stagnation and blood stasis in patients with CPID, "blood stasis,stagnation in the uterus" always implement the process of the occurrence and development of disease, this disease is an important disease machine features.4.2 Patients with qi stagnation and blood stasis type CPID, appeared different degree of anxiety and depression phenomenon will clinically, and emotional healing characteristics, plays an important role in the occurrence of disease, development and prognosis.4.3 Pelvic blood circulation disorder appear clinical patients with qi stagnation and blood stasis type CPID, immune function and blood viscosity increased and related inflammatory cytokine imbalance. Moreover, anxiety and depression in CPID patients appear in patients with qi stagnation and blood stasis type self blood rheology,complement C3, D-D and FDP value change, syndrome classification, local symptomintegral have close contact, that "blood stasis" to participate in the process of occurrence, development of qi stagnation and blood stasis type CPID.4.4 This topic research group, effect of treatment of qi stagnation and blood stasis type CPID was significantly better than the control group, especially in improving the clinical symptoms, inhibit the expression of inflammatory cells, reduce the level of hs-CRP, improve the complement C3 numerical, reduce blood viscosity, improve pelvic blood flow status of the patients, improve blood rheology index superior to control group.4.5 Traditional Chinese medicine(oral way, enema and ginger moxibustion method)administration in the treatment of qi stagnation and blood stasis type CPID, take the treatment method of multi way, multi targets, can significantly reduce the clinical symptoms and signs in patients with integral, relieve the clinical symptoms of patients,investigate its mechanism and principle, by improving local microcirculation of pelvic cavity, CPID the patients body inflammatory cell regulation, to reduce the level of hs-CRP, increased in the peripheral blood of patients with complement C3, enhanced resistance, improved immune disorder body state, weaken the secretion of proinflammatory cells, enhance the anti inflammatory cell expression, so that the body can restore the dynamic balance of the original, so as to reduce the damage state of pelvic organs.