Expression And Clinical Prognostic Significance Of Peroxiredoxin-1 In Pancreatic Carcinoma

Objective This study aims to investigate the Expression and clinical prognostic significance of peroxiredoxin-1 in pancreatic carcinoma.Methods Immunohistochemistry was used to detect Prx-1 expression in pancreatic cancer tissues and para-cancerous tissues. Enzyme-linked immunosorbent assay(ELISA) method was applied to detect the serum Prx-1 levels.Results The immunohistochemical results indicated that positive rate of Prx-1 was( p < 0.05) higher in pancreatic cancer tissues(74.4%) than in para-cancerous tissues(37.2%). The expression rates of Prx1 was correlated with TNM stage, lymph node metastasis, degree of differentiation, nerve invasion(P<0.05).Prx-1 expression was positively correlated with vascular endothelial growth factor(VEGF) and microvessel density(MVD) in cancer tissues(r = 0.315, p = 0.003),(r = 0.241, p = 0.026). The ELISA results showed that patients with pancreatic cancer had a higher serum Prx-1 level than healthy subjects. The combination of serum Prx-1 and CA19-9, the area under the curve(AUC) was significantly higher than Prx-1 sepa-rate. Positive Prx-1 expression was correlated with disappointing overall survival(OS)( p = 0.002) and disease-free survival(DFS)( p < 0.001). Multivariate analysis showed that Prx-1 staining as an independent biomarker of poor OS and DFS.Conclusions These findings suggest that the levels of Prx-1 expression are significantly increased in pancreatic cancer. Prx-1 expression was positively correlated with vascular endothelial growth factor(VEGF) and microvessel density(MVD) in cancer tissues. The up-regulated Prx-1 is closely related to tumor angiogenesis and acts as a promising tumor marker for diagnosis and prognosis of pancreatic cancer.